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Monkeypox

2 GoKawiil briefs on this topic

AlphaFold database adds 8,000+ viral protein complex structures

EMBL-EBI's AlphaFold Protein Structure Database has been expanded with more than 8,000 predicted structures of interacting protein pairs from viruses spanning 23 families that infect humans, including monkeypox virus. The addition, part of a new 'pandemic preparedness portal', builds on an earlier 2024 update that added 1.7 million interacting protein pairs from 20 organisms such as humans and tuberculosis bacteria.

Thermo Fisher Scientific Produces Monkeypox Virus Replisome Proteins for Study

Researchers expressed and purified key proteins from the monkeypox virus using Expi293F cells, including the viral polymerase complex components. The proteins were cloned, transfected, and isolated through standard cell lysis and affinity purification methods. This work enables detailed analysis of the virus's replication machinery.