Neurodegenerative Diseases

PsychAD Consortium maps gene activity across 6 million brain cells in Alzheimer's study

An NIH-funded partnership called the PsychAD Consortium has published the largest single-cell map of the human prefrontal cortex, drawing on sequencing data from more than six million cells from nearly 1,500 people. The findings appear across eight studies, including three papers in Nature, and detail gene activity in neurons, immune cells and vascular cells in this brain region tied to planning and emotional regulation.

nature.com · 2026-09-23

Personalized RNA drug shows early promise in rare ALS case

A man with a slow-progressing, genetically rare form of ALS became the first person to receive an antisense oligonucleotide therapy designed specifically to target his causal mutation. A year later, he reported improved symptoms and remains able to work as a physician, according to results published in Med.

nature.com · 2026-09-18