GoKawiilNew drug-delivery method uses molecular binding to trigger targeted cancer drug release
Researchers designed a chemical strategy that links a targeting molecule's binding action directly to the release of an anticancer payload, rather than relying solely on enzymatic cleavage. The team synthesized and validated compounds targeting fibroblast activation protein (FAP) and other markers, testing reaction rates and specificity using UPLC-mass spectrometry and antibody-based assays on proteins including PD-L1, DPPIV, and cathepsin B.