GoKawiilGPN-Star model improves prediction of functional DNA constraints across species
Researchers introduced GPN-Star, a phylogeny-informed genomic language model that outperforms established tools like PhastCons and PhyloP in identifying functional constraint and deleterious variants across the human genome. The model showed especially strong results for distal enhancers, a class of regulatory DNA that has been notoriously hard to analyze, and it learned meaningful patterns linking enhancers, transcription factor binding sites, and their co-evolution without needing labeled training data.