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Yellow Fever

2 GoKawiil briefs on this topic

US mosquito-borne diseases surge as gene-based control tech stalls in regulation

The US saw dengue cases jump to nearly 4,000 in 2024, a 360 percent rise over the prior decade's average, with local transmission in Florida, California, Texas and a public health emergency declared in Puerto Rico. Ten locally acquired malaria cases appeared in 2023, the first in twenty years, even as yellow fever-carrying mosquitoes remain present. Genetic engineering that makes male mosquitoes' offspring unable to survive, collapsing local populations, has existed since 2000 but has been stuck in regulatory limbo for roughly fifteen years.

Reference list traces two decades of systems vaccinology research foundations

This bibliography compiles foundational studies establishing systems vaccinology, a field using genomics and machine learning to predict and understand vaccine-induced immunity in humans. Key cited works include the 2009 study by Querec and colleagues, which first showed that blood transcriptional signatures could predict antibody responses to the yellow fever vaccine, and related papers on multilineage immune activation and pandemic vaccine response variability.