Researchers solved eight cryo-EM structures of human UGCG, the enzyme that gatekeeps glycosphingolipid synthesis, capturing it alone and bound to substrates, products and the drugs miglustat, ibiglustat and eliglustat. The team also ran molecular dynamics simulations and a cross-species sequence comparison spanning platypus, marsupials, elephants and other mammals to trace how UGCG regulation evolved, finding features unique to primates. All structural data, simulation files and sequences have been deposited in public repositories.
Canada's requirement that streaming services fund and feature domestic content has drawn attention as a potential irritant in trade negotiations with the United States. US officials and industry groups have pointed to these rules as a barrier that disadvantages American streaming companies operating in Canada.
In 1975, the Forest Service limited Aspen Skiing Company to a 10% lift ticket increase, from $10 to $11, after residents flooded the agency with complaints and Senator Floyd Haskell intervened. At the time, resorts on public land needed annual federal permits and routinely sought approval before raising prices.
The Dutch Data Protection Authority fined Uber roughly $966 million after finding that between 2018 and 2022 the company suspended European drivers using automated systems without meaningful human review, violating GDPR's Article 22 protections against purely automated decisions with significant consequences. The case stemmed from a 2020 complaint filed with France's CNIL by La Ligue des droits de l'Homme on behalf of over 170 drivers, and was handled by Dutch authorities since Uber's main EU base is in Amsterdam. Uber plans to appeal, arguing that fraud suspensions were brief, permanent deactivations always involved human review, and drivers had appeal options.
The Dutch Data Protection Authority has fined Uber roughly $966 million for deactivating driver accounts through automated systems without adequate human review or warning, marking one of the largest penalties issued under GDPR. The investigation stemmed from complaints, including one from former French Uber driver Brahim Ben Ali, who gathered testimony from 170 other drivers alleging similar treatment. Uber disputes the regulator's findings and plans to appeal the fine.
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