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Biological Age

10 GoKawiil briefs on this topic

Researchers push to develop standardized tests for immune system health

A commentary in Nature argues that current clinical tools—such as white blood cell counts or C-reactive protein tests—only offer a fragmented view of immune function, failing to capture whether a person's immune system is resilient or declining. The authors say advances in immunology, molecular profiling, imaging and AI could enable development of a comprehensive 'immunome' measurement to assess immune health more completely.

Death Clock app pushes blood panels, scans and supplements for longevity predictions

The Verge's Victoria Song tested Death Clock, an app that estimates users' death date and biological age using an optional blood panel bundled with its $69 annual subscription. The app recommends numerous add-on tests and purchases, including thyroid, heart and liver panels, a continuous glucose monitor, smart scale, blood pressure monitor, VO2 max evaluation, liver ultrasound, cervical cancer screening, coronary CT angiography, APOE testing and colonoscopy, claiming these could add years to a user's projected lifespan.

Ultrahuman signs Abu Dhabi deal to build nationwide biological-age model

Indian wearables startup Ultrahuman has signed a two-year MOU with the Abu Dhabi Public Health Center to build and validate a model estimating biological age by combining clinical biomarkers with wearable data. The company says the model will eventually be rolled out to people across the UAE and will work with data from devices beyond its own smart ring. Ultrahuman has sold about 800,000 smart rings globally to date.

Transplanted Hearts Show Age Reversal in Younger Recipients

A preprint study indicates that hearts transplanted into younger individuals may undergo biological rejuvenation, while those placed in older bodies exhibit signs of accelerated aging. The research, posted on bioRxiv, is yet to undergo peer review. This suggests that the biological age of a heart can adapt to its new host's age.

Former DeepMind scientist Thore Graepel says LLMs cannot truly reason

Thore Graepel, who helped build AlphaGo, has left Google DeepMind and published an opinion piece arguing that large language models lack genuine reasoning ability. He contrasts this with AlphaGo's 2016 victory over Lee Sedol, which he credits to the system's capacity for creative, reasoned decision-making. Separately, a MIT Technology Review writer reports joining a six-month competition involving roughly 500 participants aiming to reduce their biological age, tracked via a leaderboard.

NeuroAge Therapeutics CEO launches 'Younger' contest to compare biological aging clocks

Neuroscientist Christin Glorioso, founder of NeuroAge Therapeutics, has created a competition called Younger that pits participants against each other based on measurements of biological age. Entrants will submit samples to services such as TruDiagnostic, which uses epigenetic markers to estimate overall biological age, pace of aging, and the ages of 11 individual organ systems. Glorioso says the contest aims to educate the public about aging clocks and to build what she calls the world's most comprehensive dataset on them.

Scientists build 'speech clock' that estimates biological age from voice patterns

Researchers led by neuroscientist Agustín Ibáñez at Adolfo Ibáñez University created an algorithm that analyzes hundreds of vocal traits, including pitch and speaking speed, from four-minute recordings to estimate a person's age. The team found that a large gap between this speech-predicted age and a person's actual age was strongly linked to cognitive problems associated with conditions like dementia, according to findings published in Science Advances.

Study: transplanted hearts shift biological age to match recipient

Researchers led by Jesse Poganik at Harvard University report, in a bioRxiv preprint not yet peer-reviewed, that young donor hearts age faster once placed in older recipients, while older hearts appear to become biologically younger when transplanted into younger bodies. The team reached this conclusion by grafting extra hearts between mice of different ages and analyzing DNA methylation patterns linked to cellular ageing, and note similar patterns were examined in human transplant tissue.

Mouse and human heart transplant studies find donor age effect fades fast

Researchers led by Jesse Poganik at Brigham and Women's Hospital transplanted young hearts into middle-aged mice and middle-aged hearts into young mice, implanting the extra organ in the neck to compare it with the original. Using three molecular 'aging clocks' to measure biological age, the team found that transplanted hearts largely took on the biological age profile of the recipient rather than retaining the age of the donor, a pattern also suggested by records from human heart transplant recipients.

Machine perfusion found to biologically de-age donor livers before transplant

Researchers led by Adrien Longchamp and Bohan Poganik used aging clocks to show that livers pumped with oxygen and nutrients at 34 degrees on perfusion machines became biologically younger, with roughly a 30% difference compared to non-perfused organs after adjusting for chronological age. The effect persisted even after transplantation, though biological age rose in all livers once implanted, likely due to surgical stress.