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Bioprospectors mine microbial genomes for antibiotic gold

news.ycombinator.com Max Barnhart 2025-09-10 16:46:34

In brief The discovery of penicillin nearly 100 years ago started a gold rush to find new antimicrobials. Scientists mined microscopic bacteria and fungi for compounds that could help fight off infection. But over time the rate of antimicrobial discoveries slowed to a crawl. Now, modern-day bioprospectors are using genomics, synthetic biology, and AI to dig deeper than they ever have before. A new golden age of antibiotics may be upon us, say some on the hunt, though getting a drug candidate int

Topics: antimicrobial antimicrobials compound compounds says

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How Covid-19 Changed Hideo Kojima’s Vision for ‘Death Stranding 2’

wired.com Silvio Mazzitelli 2025-09-14 16:30:00

When legendary game designer Hideo Kojima announced to the world that Death Stranding 2 would soon be released, he made it known that Covid-19 had completely changed his idea for this sequel. “We released Death Stranding before the Covid-19 pandemic, when the world was moving toward isolation and division—as with Brexit. The idea behind it was ‘Let's connect. We’ll face disaster if we don’t connect.’ The theme, the story, and the gameplay of the first chapter all revolved around that idea,” Koj

Topics: death idea pandemic people stranding

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Windows 11 users want these five features back

bleepingcomputer.com Unknown 2025-09-14 06:12:22

When Windows 11 was first released, many long-time users felt features they loved had been taken away overnight. Three and a half years later, the same complaints still rise to the top of the Feedback Hub with tens of thousands of votes. Below are the five most wanted Windows 11 features on the Microsoft Feedback Hub. The most wanted requests in Windows 11 "Bring back the ability to move the taskbar to the top and sides of the screen on Windows 11" Right now, the taskbar is glued to the bot

Topics: 11 feedback microsoft taskbar windows

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Anubis ransomware adds wiper to destroy files beyond recovery

bleepingcomputer.com Unknown 2025-09-14 06:29:38

The Anubis ransomware-as-a-service (RaaS) operation has added to its file-encryptimg malware a wiper module that destroys targeted files, making recovery impossible even if the ransom is paid. Anubis (not to be confused with the same-name Android malware with a ransomware module) is a relatively new RaaS first observed in December 2024 but became more active at the beginning of the year. On February 23, the operators announced an affiliate program on the RAMP forum. A report from KELA at the

Topics: anubis encryption micro ransomware trend

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Copilot Vision brings Microsoft's screen-watching AI to everyday Windows tasks

techspot.com Alfonso Maruccia 2025-09-15 08:12:00

AI overload: Microsoft wants Copilot to be your digital sidekick, always watching and ready to help – whether you need it or not. The latest feature, Vision, turns the AI into a screen-reading assistant that talks back, offering tips, tasks, or tech-induced headaches. Microsoft announced that Copilot Vision is now available to users in the US, with plans to expand to more non-European countries soon. This update significantly enhances Copilot, which is evolving into more of a digital "companion

Topics: ai copilot microsoft users vision

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Hasbro’s ‘Star Wars’ SDCC Exclusive Is the Ultimate ‘Revenge of the Sith’ Set

gizmodo.com Germain Lussier 2025-09-15 12:45:36

Dark side, light side, it doesn’t matter. This year’s Hasbro Star Wars exclusive at San Diego Comic-Con is certainly the chosen one, and we’re going to take the high ground to acquire it. Celebrating 20 years of Star Wars Episode III: Revenge of the Sith, Hasbro just revealed a six-inch Black Series set, exclusively for release at San Diego Comic-Con, of Anakin Skywalker and Obi-Wan Kenobi and their epic lightsaber duel over the lava on Mustafar. Retailing for $110, the set will first be availa

Topics: comic diego figures star wars

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Microsoft's own Xbox handheld is "essentially cancelled"

techspot.com Kishalaya Kundu 2025-09-15 16:01:00

TL;DR: Microsoft and Asus recently announced two new Xbox-branded handheld devices: the ROG Xbox Ally and ROG Xbox Ally X. While these represent a new step for Xbox gaming on portable devices, a new report suggests that Microsoft has internally shelved its own Xbox handheld project – one that was never officially announced but had been the subject of considerable speculation. According to The Verge, Microsoft has "essentially canceled" its native Xbox handheld to focus on the Xbox software plat

Topics: devices handheld microsoft new xbox

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Best Buy’s Giving You $1,000 Off Refurbished Microsoft Surface Touchscreen Laptop, Nearly Free Right Now

gizmodo.com Joe Tilleli 2025-09-15 16:10:11

Looking to replace you laptop but don’t feel like shelling out thousands for the latest MacBook? Well you don’t need to sweat. You can grab yourself something perfectly capable of meeting your everyday needs. New is overrated. Like-new is good enough for just about anything and is a great way to save yourself hundreds and hundreds of dollars. What happens to new products anyway? Well I’ll tell you. They become old. It happens to us all. Stop trying to fight the entropy of the universe and just a

Topics: just laptop microsoft new surface

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Boston Dynamics robots dance to ‘Don’t Stop Me Now’ for ‘America’s Got Talent’ audition

techcrunch.com Amanda Silberling 2025-09-15 20:36:44

A dance crew of four-legged robots from Boston Dynamics appeared on “America’s Got Talent” to perform a synchronized routine to Queen’s “Don’t Stop Me Now.” Their performance was impressive enough to earn four “yes” votes from the judges — but one of the five robots experienced some stage fright, perhaps, and shut down in the middle of the routine. But the show must go on, so nevertheless, the four other robots persisted. “Can I be honest with you?” judge Simon Cowell asked at the conclusion o

Topics: boston don dynamics performance robots

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Microsoft confirms auth issues affecting Microsoft 365 users

bleepingcomputer.com Unknown 2025-09-16 12:37:06

Microsoft is investigating an ongoing incident that is causing users to experience errors with some Microsoft 365 authentication features. As the company revealed earlier today in an incident alert published in the admin center, users may experience errors during self-service password resets, while admins may be unable to add multi-factor authentication (MFA) sign-in methods to some users. Redmond says this incident is caused by a recent change aiming to improve MFA sign-in functionality. Sinc

Topics: 365 authentication incident mfa microsoft

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HP’s 2025 New 14″ Laptop at Over 70% Off Makes It Almost Free, With MS Office and Windows 11 Pro Included

gizmodo.com Joe Tilleli 2025-09-16 12:10:58

Schools is out but the next semester will be here before you know it. Is you college student equipped to take on all their classes? Make sure they are kitted with the right laptop to get all their class work and homework done reliably without any technical issues. Amazon is making that easy as they’ve knocked more than half the price off this HP portable student and business laptop. It includes Microsoft Office and also thrown into the bundle is a license for Windows 11 Pro. It’s down from $1,30

Topics: college laptop microsoft office student

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Poop Transplants Not All They’re Cracked Up to Be

gizmodo.com Ellyn Lapointe 2025-09-16 20:00:21

Fecal transplants have emerged as a potential treatment for a wide range of conditions, including irritable bowel syndrome, diabetes, and even depression. These so-called poop transplants have understandably received a lot of attention, but new research casts a bit of a wet blanket over the practice. The procedure involves taking microbes from the poop of a healthy person and transferring them into a patient’s colon. This should restore balance to their gut microbiome, but according to a study

Topics: fecal gut microbes parts transplants

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Patch Tuesday, June 2025 Edition

krebsonsecurity.com Unknown 2025-09-14 15:10:53

Microsoft today released security updates to fix at least 67 vulnerabilities in its Windows operating systems and software. Redmond warns that one of the flaws is already under active attack, and that software blueprints showing how to exploit a pervasive Windows bug patched this month are now public. The sole zero-day flaw this month is CVE-2025-33053, a remote code execution flaw in the Windows implementation of WebDAV — an HTTP extension that lets users remotely manage files and directories

Topics: 2025 cve microsoft month windows

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Major sugar substitute found to impair brain blood vessel cell function

news.ycombinator.com Justin Jackson 2025-09-16 15:05:00

This article has been reviewed according to Science X's editorial process and policies . Editors have highlighted the following attributes while ensuring the content's credibility: Credit: Pixabay/CC0 Public Domain Erythritol may impair cellular functions essential to maintaining brain blood vessel health, according to researchers at the University of Colorado Boulder. Findings suggest that erythritol increases oxidative stress, disrupts nitric oxide signaling, raises vasoconstrictive peptide

Topics: approximately endothelial erythritol microvascular oxide

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LibreOffice backs campaign to help users move from Windows 10 to Linux – and ditch Office, too

techspot.com Alfonso Maruccia 2025-09-17 20:31:00

In context: Microsoft will officially end support for the most widely used editions of Windows 10 in just a few months. The operating system remains in use by hundreds of millions of PC owners, many of whom will soon face a critical decision: upgrade to Windows 11, or explore alternatives. Microsoft plans to end support for Windows 10 security updates on October 14, 2025, even though the operating system remains the most widely used desktop platform. This move will render a massive number of PC

Topics: libreoffice linux microsoft users windows

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Microsoft fixes first known zero-click attack on an AI agent

techspot.com Kishalaya Kundu 2025-09-18 00:48:00

TL;DR: Microsoft has patched a critical zero-click vulnerability in Copilot that allowed remote attackers to automatically exfiltrate sensitive user data simply by sending an email. Dubbed "EchoLeak," the security flaw is being described by cybersecurity researchers as the first known zero-click attack targeting an AI assistant. EchoLeak affected Microsoft 365 Copilot, the AI assistant integrated across several Office applications, including Word, Excel, Outlook, PowerPoint, and Teams. Accordin

Topics: ai aim echoleak microsoft security

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Unpacking AI Agents

wired.com Lauren Goode 2025-09-18 00:46:05

In the past six months, OpenAI, Anthropic, Google, and others have released web-browsing agents that are designed to complete tasks independently, with only minimal input from humans. OpenAI CEO Sam Altman has even called AI agents “the next giant breakthrough.” On today’s episode, we'll dive into what makes these agents different from other forms of machine intelligence, and whether their capabilities can live up to the hype. You can follow Michael Calore on Bluesky at @snackfight, Lauren Good

Topics: agents calore lauren michael wired

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Microsoft's Copilot Vision AI helper is now available on Windows in the US

engadget.com Unknown 2025-09-18 04:00:34

Microsoft has begun rolling out a major update for Copilot. Starting today, Windows 10 and 11 users in the US can try out the assistant's Vision feature. The tool allows you to share up to two apps with Copilot, so that you can then chat about what it sees. "[Copilot Vision] acts as your second set of eyes, able to analyze content, help when you’re lost, provide insights, and answer your questions as you go," Microsoft says. Additionally, with its new Highlights functionality, Copilot can even

Topics: apps copilot microsoft says vision

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Microsoft just teased its next-gen Xbox console, and nobody noticed

theverge.com Tom Warren 2025-09-18 04:00:00

is a senior editor and author of Notepad , who has been covering all things Microsoft, PC, and tech for over 20 years. I feel like a broken record, but I’ve been writing for more than a year that the next Xbox console will be more PC-like. Now, I think Microsoft just teased its next-gen Xbox plans while announcing its partnership with Asus to bring two Xbox Ally handhelds to the market later this year. The Xbox Ally handhelds run Windows, but the Xbox team has worked with Windows engineers to

Topics: games microsoft pc windows xbox

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Microsoft’s new Copilot Vision can ‘see’ your apps on Windows

theverge.com Tom Warren 2025-09-18 04:00:00

is a senior editor and author of Notepad , who has been covering all things Microsoft, PC, and tech for over 20 years. Microsoft is launching Copilot Vision for Windows today, an extension of its AI assistant that lets you share your screen or apps so that Copilot can do things like coach you through using Adobe Photoshop features or analyze the photos and webpages you’re looking at. “When you choose to enable it, Copilot Vision can see what you see and talk to you about it in real time,” says

Topics: copilot microsoft share vision windows

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Two exploits are threatening Secure Boot, but Microsoft is only patching one of them

techspot.com Alfonso Maruccia 2025-09-18 08:23:00

Facepalm: Microsoft and the PC industry developed the Secure Boot protocol to prevent modern UEFI-based computers from being hacked or compromised during the boot process. However, just a few years later, the technology is plagued by a steady stream of serious security vulnerabilities. Cybercriminals are currently having a field day with Secure Boot. Security experts have uncovered two separate vulnerabilities that are already being exploited in the wild to bypass SB's protections. Even more co

Topics: boot cve microsoft secure security

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Microsoft Edge now offers secure password deployment for businesses

bleepingcomputer.com Unknown 2025-09-18 16:20:31

Microsoft announced that a new Edge feature allowing employees to share passwords more securely in enterprise environments has reached general availability. Known as secure password deployment, this feature will be available to Microsoft Edge for Business users starting this week, minimizing the risk of unauthorized access by ensuring that employees don't accidentally share passwords with unintended recipients. The feature is available for Microsoft 365 Business Premium, E3, and E5 subscriptio

Topics: edge microsoft password passwords secure

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Apple's Game App on iPhone vs. Microsoft's ROG Xbox Ally: The Real Winners Are Gamers

cnet.com See Full Bio 2025-09-18 15:00:14

At WWDC 2025, Apple showed off plenty of changes in its preview for software upgrades due out later this year, but alongside visual shifts like Liquid Glass, the company also debuted a new Games app designed to be a hub for downloaded games. It's a continued push for iPhone, iPad and Mac owners to play and connect with others that comes as other gaming companies shift their strategies -- most notably, Apple announced its Games app days after Microsoft revealed its own ROG Xbox Ally, a powerful

Topics: apple games microsoft play xbox

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Windows 11 24H2 emergency update fixes Easy Anti-Cheat BSOD issue

bleepingcomputer.com Unknown 2025-09-19 04:43:04

Microsoft has released an emergency Windows 11 24H2 update to address an incompatibility issue triggering restarts with blue screen of death (BSOD) errors on systems with Easy Anti-Cheat. The out-of-band update (KB5063060) is a revised version of the Windows 11 KB5060842 cumulative update released during this month's Patch Tuesday after many customers reported experiencing system reboots and IRQL_NOT_LESS_OR_EQUAL BSODs tied to ntoskrnl.exe or EasyAntiCheat_EOS.exe crashing on computers running

Topics: anti devices microsoft update windows

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Danish Ministry Replaces Windows and Microsoft Office with Linux and LibreOffice

news.ycombinator.com Martin Holland 2025-09-19 02:37:22

The Danish Ministry of Digitization is to completely abandon Microsoft in the coming months and use Linux instead of Windows and switch from Office 365 to LibreOffice. Minister Caroline Stage (Moderaterne) announced this in an interview with the daily newspaper Politiken. It comes just a few days after the country's two largest municipalities initiated similar steps. This summer, half of the ministry's employees will be equipped with Linux and LibreOffice. If everything goes as expected, the ent

Topics: digitalization far microsoft ministry politiken

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OpenAI will reportedly start using Google's cloud servers

engadget.com Unknown 2025-09-17 15:23:12

This is another move by the company to diversify its compute portfolio beyond Microsoft Azure. OpenAI has inked a deal with Google to begin using the latter's cloud service to meet its growing needs for increased computing capacity, according to a report by Reuters . This is something of a surprise, given that Google and OpenAI are rivals in the AI space. The terms of the deal remain unknown, but reporting indicates it has been in the negotiation phase for the past several months. This marks O

Topics: cloud deal google microsoft openai

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Startup aims to shrink particle accelerators to transform semiconductor manufacturing

techspot.com Skye Jacobs 2025-09-18 21:03:00

Something to look forward to: In a modest laboratory tucked beneath the offices of Y Combinator in San Francisco, a young startup is working to upend one of the most entrenched technologies in chip manufacturing. Inversion Semiconductor, founded in 2024 by Rohan Karthik and Daniel Vega, is betting that shrinking particle accelerators down to tabletop size could unlock a new era of faster, more powerful semiconductor production. Today, the world's most advanced chips are made with extreme ultrav

Topics: inversion light lithography new semiconductor

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Xbox handheld console finally revealed after a decade of speculation

feeds.bbci.co.uk Unknown 2025-09-16 19:07:34

Xbox handheld console finally revealed after a decade of speculation 3 days ago Share Save Tom Gerken Technology reporter Share Save Xbox Microsoft has finally revealed its highly-anticipated handheld console, years after it was first rumoured. The ROG Xbox Ally will let gamers access their Game Pass subscription library on-the-go, in effect meaning members will start off with hundreds of games. It is being made in partnership with Asus, which has been making handheld gaming devices since 202

Topics: game handheld microsoft new xbox

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Microsoft creates separate Windows 11 24H2 update for incompatible PCs

bleepingcomputer.com Unknown 2025-09-19 00:35:10

Microsoft confirmed on Tuesday that it's pushing a revised security update targeting some Windows 11 24H2 systems incompatible with the initial update released during this month's Patch Tuesday. "This update is being gradually rolled out to devices running Windows 11, version 24H2. We've identified a compatibility issue affecting a limited set of these devices," the company said in a Twitter thread. "If your device is affected, you'll receive a revised update with all the June 2025 security im

Topics: issue microsoft tuesday update windows

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Zero-click AI data leak flaw uncovered in Microsoft 365 Copilot

bleepingcomputer.com Unknown 2025-09-19 02:48:50

A new attack dubbed 'EchoLeak' is the first known zero-click AI vulnerability that enables attackers to exfiltrate sensitive data from Microsoft 365 Copilot from a user's context without interaction. The attack was devised by Aim Labs researchers in January 2025, who reported their findings to Microsoft. The tech giant assigned the CVE-2025-32711 identifier to the information disclosure flaw, rating it critical, and fixed it server-side in May, so no user action is required. Also, Microsoft no

Topics: attack data echoleak llm microsoft

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Latest Tech News

Bioprospectors mine microbial genomes for antibiotic gold

How Covid-19 Changed Hideo Kojima’s Vision for ‘Death Stranding 2’

Windows 11 users want these five features back

Anubis ransomware adds wiper to destroy files beyond recovery

Copilot Vision brings Microsoft's screen-watching AI to everyday Windows tasks

Hasbro’s ‘Star Wars’ SDCC Exclusive Is the Ultimate ‘Revenge of the Sith’ Set

Microsoft's own Xbox handheld is "essentially cancelled"

Best Buy’s Giving You $1,000 Off Refurbished Microsoft Surface Touchscreen Laptop, Nearly Free Right Now

Boston Dynamics robots dance to ‘Don’t Stop Me Now’ for ‘America’s Got Talent’ audition

Microsoft confirms auth issues affecting Microsoft 365 users

HP’s 2025 New 14″ Laptop at Over 70% Off Makes It Almost Free, With MS Office and Windows 11 Pro Included

Poop Transplants Not All They’re Cracked Up to Be

Patch Tuesday, June 2025 Edition

Major sugar substitute found to impair brain blood vessel cell function

LibreOffice backs campaign to help users move from Windows 10 to Linux – and ditch Office, too

Microsoft fixes first known zero-click attack on an AI agent

Unpacking AI Agents

Microsoft's Copilot Vision AI helper is now available on Windows in the US

Microsoft just teased its next-gen Xbox console, and nobody noticed

Microsoft’s new Copilot Vision can ‘see’ your apps on Windows

Two exploits are threatening Secure Boot, but Microsoft is only patching one of them

Microsoft Edge now offers secure password deployment for businesses

Apple's Game App on iPhone vs. Microsoft's ROG Xbox Ally: The Real Winners Are Gamers

Windows 11 24H2 emergency update fixes Easy Anti-Cheat BSOD issue

Danish Ministry Replaces Windows and Microsoft Office with Linux and LibreOffice

OpenAI will reportedly start using Google's cloud servers

Startup aims to shrink particle accelerators to transform semiconductor manufacturing

Xbox handheld console finally revealed after a decade of speculation

Microsoft creates separate Windows 11 24H2 update for incompatible PCs

Zero-click AI data leak flaw uncovered in Microsoft 365 Copilot

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