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SDR42E1 modulates Vitamin D absorption and cancer pathogenesis

news.ycombinator.com Hendi 2026-01-02 11:06:43

Conclusion: These findings establish SDR42E1 as a key modulator of vitamin D-related pathways and highlight its potential as a therapeutic target for addressing vitamin D deficiency and associated pathologies, including cancer. Results: Integrated transcriptomic and proteomic analyses revealed significant dysregulation of sterol absorption and metabolism (fold change (FC) = 1.8, P = 0.007) and cancer-related signaling pathways (FC = −1.7, P = 0.02). Notably, key differentially expressed genes i

Topics: 10 fc sdr42e1 value vitamin

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Conduct rules are coming for Google and Apple in the UK

arstechnica.com Unknown 2026-01-02 11:46:04

Apple and Google face new rules governing how they run their smartphone software and app stores in the UK, as Britain’s antitrust agency looks to impose new European-style controls on the Big Tech companies. The proposed interventions could trim fees of up to 30 percent that Apple and Google charge for digital transactions through their mobile app stores, as well as prevent them from designing their systems to favor their own apps and services. The UK’s Competition and Markets Authority on Wed

Topics: agency app apple digital services

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Apple's Liquid Glass: When Aesthetics Beat Function

news.ycombinator.com Unknown 2026-01-02 15:46:09

I watched the initial presentation during WWDC 2025. My initial thought was: they're getting people used to transparent UIs for spatial computing (mixed reality environments where digital interfaces blend with the physical world). My immediate second thought was, 'wow, you can't read a thing - are they serious?'. Skeuomorphism done right (and wrong) Designers have always borrowed from the real world, though these metaphors often outlive their origins. The universal save icon? Still a floppy di

Topics: apple computing digital metaphors real

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How Virtual Design Can Change the Future of Research and Development

computer.org Laurel Tweed 2026-01-05 00:00:40

Integrating physical and virtual testing environments into research and development (R&D) is rapidly moving from a cutting-edge concept to standard practice across many industries. Organizations that take this approach gain a variety of benefits that improve efficiency. Among the advantages is the ability to minimize prototype builds, optimize test cell usage, and enable faster design iterations through digital twin technology and data feedback loops between physical testing and engineering mode

Topics: data digital physical testing virtual

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Headspace annual subscriptions are 40 percent off right now

engadget.com Unknown 2026-01-05 06:28:52

Engadget has been testing and reviewing consumer tech since 2004. Our stories may include affiliate links; if you buy something through a link, we may earn a commission. Read more about how we evaluate products . Like any habit, maintaining a meditation practice can be challenging. Having the right tools can make it a bit easier, which is why we're excited to see a subscription to Headspace is back on sale. Right now, you can get one year of Headspace for $42, down from $70. The 40 percent disc

Topics: best courses engadget headspace meditation

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Three things veteran planetary health investors look for in a startup

techcrunch.com Tim De Chant 2026-01-05 11:00:00

Ask any founder or investor: fundraising is never easy. And in a market with this level of uncertainty, the difficulties are compounded. “Everyone has to go through fundraising, and it’s a relatively challenging market right now,” Kyle Teamey, managing partner at RA Capital Planetary Health, told TechCrunch. “That’s good for a bit of empathy.” Teamey and his colleague Brigid O’Brien, also a managing partner with the firm, know this as well as anyone. They just closed a $120 million fund, their

Topics: brien capital market said teamey

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We have made the decision to not continue paying for BBB accreditation

news.ycombinator.com Unknown 2026-01-05 17:49:29

We have made the conscious choice not to continue paying for accreditation from the Better Business Bureau (BBB). We realize that this may raise questions among our customers, and we want to explain why we made this decision. For years, people have been told to look for BBB accredited businesses, and that it somehow reflects whether a business is on the up and up. What most don’t realize is that businesses PAY to be accredited with the BBB. You do not EARN an accreditation- you buy it. A few m

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We Have Made the Decision to Not Continue Paying for BBB Accreditation

news.ycombinator.com Unknown 2026-01-05 23:49:29

We have made the conscious choice not to continue paying for accreditation from the Better Business Bureau (BBB). We realize that this may raise questions among our customers, and we want to explain why we made this decision. For years, people have been told to look for BBB accredited businesses, and that it somehow reflects whether a business is on the up and up. What most don’t realize is that businesses PAY to be accredited with the BBB. You do not EARN an accreditation- you buy it. A few m

Topics: accreditation bbb business customers don

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Hidden Sensors Reveal Filthy Truth About Handwashing in Hospital Bathrooms

gizmodo.com Ed Cara 2026-01-06 16:15:51

Here’s something that will make you lose just a bit more faith in humanity—or at least reach for some hand wipes. New research shows that even in hospitals, a substantial number of people aren’t bothering to wash their hands. Scientists from the University of Surrey in England led the study, installing sensors near hospital toilet and sink pipes to keep track of people’s handwashing. Nearly half of toilet users skipped the sink after flushing, they found. The researchers say more effective stra

Topics: handwashing hospitals like people university

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Titan’s Methane Lakes Could Form Bubble-Like Structures Essential to Life, Scientists Say

gizmodo.com Passant Rabie 2026-01-08 10:00:06

On December 25, 2004, the Huygens probe separated from the Cassini spacecraft and landed on Titan’s sandy surface. The probe survived for 72 hours on Saturn’s largest moon, revealing a world that is chemically complex and more Earth-like than expected. For years, scientists have been intrigued by Titan as an alien world that might have the right conditions to host life, albeit in a very different form than on Earth. New research by NASA reveals that molecular precursors to life could form in Tit

Topics: earth form life surface titan

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At Least 750 US Hospitals Faced Disruptions During Last Year’s CrowdStrike Outage, Study Finds

wired.com Andy Greenberg 2026-01-08 06:54:06

When, one year ago today, a buggy update to software sold by the cybersecurity firm CrowdStrike took down millions of computers around the world and sent them into a death spiral of repeated reboots, the global cost of all those crashed machines was equivalent to one of the worst cyberattacks in history. Some of the various estimates of the total damage worldwide have stretched well into the billions of dollars. Now a new study by a team of medical cybersecurity researchers has taken the first

Topics: crowdstrike health hospitals network networks

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AI capex is so big that it's affecting economic statistics

news.ycombinator.com Unknown 2026-01-08 18:59:04

AI capex is so big that it's affecting economic statistics, boosting the economy, and beginning to approach the railroad boom As ever, here is what's ahead: Updates on prior pieces My most recent Rough Notes essay A few things worth reading I previously wrote about the perils of building renovation as a Fed chair, especially given an administration bent on finding a reason to fire you "for cause." As anyone who has renovated anything larger than a dog house knows, no one thinks what you spent

Topics: ai capex capital datacenter spending

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The 5 Best Multivitamins for Men in 2025

cnet.com See Full Bio 2026-01-08 18:03:00

The Academy of Nutrition and Dietetics recommends that men who are missing key vitamins from their diets, lack regular physical activity or adequate amounts of sleep take a multivitamin. Men specifically require a multivitamin that contains some of the following. Vitamin A Found in cantaloupe, carrots, eggs and milk, vitamin A (along with carotenoids, a version of vitamin A found in plant sources) is important for eye health. According to the CDC, only 10% of US adults meet the vegetable intak

Topics: daily health men multivitamin vitamin

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AI CapEx Is Eating the Economy

news.ycombinator.com Unknown 2026-01-09 00:59:04

AI capex is so big that it's affecting economic statistics, boosting the economy, and beginning to approach the railroad boom As ever, here is what's ahead: Updates on prior pieces My most recent Rough Notes essay A few things worth reading I previously wrote about the perils of building renovation as a Fed chair, especially given an administration bent on finding a reason to fire you "for cause." As anyone who has renovated anything larger than a dog house knows, no one thinks what you spent

Topics: ai capex capital datacenter spending

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Trump’s Cabinet Is Cashing in on Crypto

gizmodo.com Aj Dellinger 2026-01-09 02:00:21

Congress’s big “Crypto Week” might have faded into the background a bit due to cryptic messages Donald Trump left in a birthday note to Jeffrey Epstein, but Republicans in the House and Senate did, in fact, manage to pass a couple of laws that will establish loose, industry-friendly regulations for cryptocurrency. Which means it is a perfect time to be reminded that the Trump administration is packed with people who stand to benefit from cryptocurrency being mainstreamed. Trump himself, of cour

Topics: administration crypto digital million trump

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Rocket Report: SpaceX won’t land at Johnston Atoll; new North Sea launch site

arstechnica.com Unknown 2026-01-11 03:15:11

Welcome to Edition 8.03 of the Rocket Report! We are at an interesting stage in Europe, with its efforts to commercialize spaceflight. Finally, it seems the long-slumbering continent is waking up to the need to leverage private capital to drive down the costs of space access, and we are seeing more investment flow into European companies. But it is critical that European policymakers make strategic investments across the industry or companies like PLD Space, which outlined big plans this week, w

Topics: avio european italy launch space

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The crypto industry got what it paid for

theverge.com Lauren Feiner 2026-01-10 11:37:44

is a senior policy reporter at The Verge, covering the intersection of Silicon Valley and Capitol Hill. She spent 5 years covering tech policy at CNBC, writing about antitrust, privacy, and content moderation reform. The crypto industry is beginning to see a return on one of its most prescient investments: Donald Trump. On Thursday, the House of Representatives passed three bills that industry supporters believe will bring more legitimacy and predictability to the digital currency space — and

Topics: bills crypto digital industry trump

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Citrix Bleed 2 exploited weeks before PoCs as Citrix denied attacks

bleepingcomputer.com Unknown 2026-01-11 06:37:34

A critical Citrix NetScaler vulnerability, tracked as CVE-2025-5777 and dubbed "CitrixBleed 2," was actively exploited nearly two weeks before proof-of-concept (PoC) exploits were made public, despite Citrix stating that there was no evidence of attacks. GreyNoise has confirmed its honeypots detected targeted exploitation from IP addresses located in China on June 23, 2025. "GreyNoise has observed active exploitation attempts against CVE-2025-5777 (CitrixBleed 2), a memory overread vulnerabili

Topics: 2025 citrix exploitation kill netscaler

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These Are the 6 Best Vitamins and Minerals for Older Adults, According to Experts

cnet.com See Full Bio 2026-01-12 04:50:00

Getting a good selection of vitamins and minerals in your diet is vital to staying fit and healthy, and that shouldn't be a shock to anyone at this point. If you have a balanced diet, you're likely already getting the nutrients that you need. But that can change, especially as we age and our bodies demand more. Older people are at an increased risk of low vitamin consumption -- partly because our bodies can no longer absorb certain nutrients as effectively as they once did. So, if you're dealing

Topics: health magnesium said vitamin zinc

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Hadrian raises $260M to build out automated factories for space and defense parts

techcrunch.com Aria Alamalhodaei 2026-01-12 06:16:15

Investors are continuing to rally behind the call to reindustrialize American industry, this time by building out a $260 million war chest for automated manufacturing startup Hadrian to scale its factory footprint and make even more machine parts. Hadrian’s aim is to modernize American manufacturing by leveraging advanced automation to deliver mass-produced parts for aerospace and defense companies at a fraction of the time. It’s a huge change to the status quo: a manufacturing industry that’s

Topics: capital disrupt factory hadrian new

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Retro gaming YouTuber Once Were Nerd sued and raided by the Italian government

news.ycombinator.com Unknown 2026-01-13 04:17:08

TL;DR Retro gaming YouTuber Once Were Nerd has been sued and raided by the Italian government. Consoles were seized and channels may be closed for promoting piracy of copyrighted material. Some of these devices ship with pre-loaded ROMs, which appears to be the source of the complaint. While gaming content continues to grow and thrive on video platforms like Twitch and YouTube, copyright remains a sticky issue. Most companies look the other way when it comes to game streaming, but emulation i

Topics: anbernic copyright gaming italian law

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Crypto accumulator DeFi Development to expand globally by franchising its Solana treasury model

cnbc.com Tanaya Macheel 2026-01-13 22:52:21

DeFi Development , a company vying to be the MicroStrategy of Solana, is expanding internationally through a franchise model. The company plans to partner with others looking to operate their own Solana treasuries with DeFi's support. In return, DeFi Development will retain an equity stake in each regional vehicle. The initiative will be branded DFDV Treasury Accelerator. "Most crypto treasury vehicles today are following the MicroStrategy model. What excites us about DFDV is that they're not

Topics: capital defi sol solana treasury

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A 1960s schools experiment that created a new alphabet

news.ycombinator.com Emma Loffhagen 2026-01-11 18:33:24

Throughout my life, my mum has always been a big reader. She was in three or four book clubs at the same time. She’d devour whatever texts my siblings and I were studying in school, handwrite notes for our lunchboxes and write in her diary every night. Our fridge door was a revolving display of word-of-the-day flashcards. Despite this, she also was and remains, by some margin, the worst speller I have met. By the time I was in primary school, she was already asking me to proofread her work emai

Topics: children english ita says spelling

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How these proposed standards aim to tame our AI wild west

zdnet.com Joe Mckendrick 2026-01-13 23:00:19

ferrantraite/Getty Images Technology standardization has been something of an elusive holy grail, with new tech emerging faster than standards groups can keep up. Yet, somehow, things eventually come together -- at least for mature systems -- and achieve interoperability, be it email networks or developer tools. Now, a new race against time has come to the fore, with efforts to tame one of the fastest-developing technologies seen to date -- artificial intelligence. Can standards groups, with t

Topics: ai content digital standards trust

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The 1960s schools experiment that created a whole new alphabet

news.ycombinator.com Emma Loffhagen 2026-01-12 06:33:24

Throughout my life, my mum has always been a big reader. She was in three or four book clubs at the same time. She’d devour whatever texts my siblings and I were studying in school, handwrite notes for our lunchboxes and write in her diary every night. Our fridge door was a revolving display of word-of-the-day flashcards. Despite this, she also was and remains, by some margin, the worst speller I have met. By the time I was in primary school, she was already asking me to proofread her work emai

Topics: children english ita says spelling

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The Big Beautiful Bill Is Bad for Americans’ Health and Wallets, Study Finds

gizmodo.com Ed Cara 2026-01-14 21:42:42

The “Big Beautiful Bill” is now law, and it’s poised to wreak plenty of destruction. Research out today finds that the policy changes will lead to thousands more deaths annually, as well as harm the financial health of rural hospitals. Epidemiologists at the University of California, San Francisco, and elsewhere conducted the study. They found the Medicaid cuts caused by the Big Beautiful Bill will cause many avoidable hospitalizations and deaths, put dozens of rural hospitals at high risk of c

Topics: changes coverage health hospitals medicaid

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How to Watch Norway vs. Italy From Anywhere for Free: Stream UEFA Women's Euro 2025 Soccer

cnet.com See Full Bio 2026-01-15 00:00:07

The first quarterfinal of the 2025 Women's Euros sees a repeat of the 1993 final, as Norway face off against Italy in Geneva. Below, we'll outline the best live TV streaming services to use to watch this match as it happens, wherever you are in the world, and how to use a VPN if the game isn't available where you are. The Norwegians navigated the group stage in impressive style, with Gemma Grainger's team winning all three of their games against Switzerland, Finland and Iceland. Italy's route

Topics: italy soccer streaming vpn watch

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Forget copyright strikes, a retro gaming YouTuber faces possible jail time for reviewing gaming handhelds

androidauthority.com Unknown 2026-01-15 11:51:56

TL;DR Retro gaming YouTuber Once Were Nerd has been sued and raided by the Italian government. Consoles were seized and channels may be closed for promoting piracy of copyrighted material. Some of these devices ship with pre-loaded ROMs, which appears to be the source of the complaint. While gaming content continues to grow and thrive on video platforms like Twitch and YouTube, copyright remains a sticky issue. Most companies look the other way when it comes to game streaming, but emulation i

Topics: anbernic copyright gaming italian law

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Circle stock drops after House blocks key procedural vote on stablecoin legislation

cnbc.com Mackenzie Sigalos 2026-01-17 16:50:21

Circle Internet Group Initial Public Offering at the New York Stock Exchange in New York City, U.S., June 5, 2025. Circle shares slid on Tuesday after the U.S. House of Representatives failed to clear a key procedural hurdle that would have teed up votes on long-awaited crypto-related bills. The move dealt a major setback to the digital asset industry, which had framed this week as a turning point for regulatory clarity in Washington, D.C. Circle, the stablecoin issuer that's soared in value

Topics: circle crypto digital house industry

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See How ‘M3GAN 2.0’ Built Itself a Bigger, Better M3GAN

gizmodo.com James Whitbrook 2026-01-17 21:00:07

For better or worse, M3GAN’s sophomore outing in M3GAN 2.0 brought with it much more action-packed mania than the killer-doll horrors of the original. That, and of course the awkward inconvenience of M3GAN’s body being destroyed in the climax of the first film, meant her return for round two needed a mechanical do-over… including a few upgrades for good measure. Now that M3GAN 2.0 is heading home digitally today, you can see just how the team behind the movie made those upgrades to make the all

Topics: animatronic digitally including m3gan movie

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Latest Tech News

SDR42E1 modulates Vitamin D absorption and cancer pathogenesis

Conduct rules are coming for Google and Apple in the UK

Apple's Liquid Glass: When Aesthetics Beat Function

How Virtual Design Can Change the Future of Research and Development

Headspace annual subscriptions are 40 percent off right now

Three things veteran planetary health investors look for in a startup

We have made the decision to not continue paying for BBB accreditation

We Have Made the Decision to Not Continue Paying for BBB Accreditation

Hidden Sensors Reveal Filthy Truth About Handwashing in Hospital Bathrooms

Titan’s Methane Lakes Could Form Bubble-Like Structures Essential to Life, Scientists Say

At Least 750 US Hospitals Faced Disruptions During Last Year’s CrowdStrike Outage, Study Finds

AI capex is so big that it's affecting economic statistics

The 5 Best Multivitamins for Men in 2025

AI CapEx Is Eating the Economy

Trump’s Cabinet Is Cashing in on Crypto

Rocket Report: SpaceX won’t land at Johnston Atoll; new North Sea launch site

The crypto industry got what it paid for

Citrix Bleed 2 exploited weeks before PoCs as Citrix denied attacks

These Are the 6 Best Vitamins and Minerals for Older Adults, According to Experts

Hadrian raises $260M to build out automated factories for space and defense parts

Retro gaming YouTuber Once Were Nerd sued and raided by the Italian government

Crypto accumulator DeFi Development to expand globally by franchising its Solana treasury model

A 1960s schools experiment that created a new alphabet

How these proposed standards aim to tame our AI wild west

The 1960s schools experiment that created a whole new alphabet

The Big Beautiful Bill Is Bad for Americans’ Health and Wallets, Study Finds

How to Watch Norway vs. Italy From Anywhere for Free: Stream UEFA Women's Euro 2025 Soccer

Forget copyright strikes, a retro gaming YouTuber faces possible jail time for reviewing gaming handhelds

Circle stock drops after House blocks key procedural vote on stablecoin legislation

See How ‘M3GAN 2.0’ Built Itself a Bigger, Better M3GAN

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