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Florida Cat Named Pepper Brings Home Never-Before-Seen Virus—for the Second Time

Last year, Pepper, a pet cat who roams the backyards of Gainesville, Florida, helped a scientist discover a new viral strain. Now, the furry feline is back at it again. In a new study, scientists have once again discovered an exotic virus infecting a dead rodent that had been caught by Pepper. This time around, Pepper’s furry hunting trophy helped researchers pinpoint an unidentified strain of orthoreovirus, a type of virus that infects humans and other mammals. The findings, and the virus’s co

Publishing Pepys

Two hundred years ago this month, Samuel Pepys’s diary was published to great acclaim. Readers of the first edition in 1825 relished Pepys’s ‘honest’ observations and ‘private anecdotes’. While writing his journal in the 1660s, Pepys had worked hard to keep it secret. He knew he was placing his livelihood at risk by recording seditious criticisms of his superiors, along with details of his own bribe-taking and sexually explicit accounts of his ‘amours’. There was much that, when writing, he did

Fun with uv and PEP 723

Fun with uv and PEP 723 June 24, 2025 For the longest time, I have been frustrated with Python because I couldn’t use it for one-off scripts. I had to first ensure it was running in an environment where it could find the right Python version and the dependencies installed. That is now a thing of the past. If you are not a Pythonista (or one possibly living under a rock), uv is an extremely fast Python package and project manager, written in Rust. uv also provides this nifty tool called uvx (k

Topics: pep python script sys uv

Toxic Proteins for Drug Discovery

Noah Whiteman, professor of evolutionary biology at UC Berkeley, writes about how toxins are repurposed into medicines for Issue 06. Whiteman’s recent book is called “Most Delicious Poison.” Ella Watkins-Dulaney for Asimov Press. When you hear the word "poison," perhaps you picture a Victorian-era cobalt bottle labeled "NOT TO BE TAKEN" or the iconic pictogram of a leering skull and crossbones. What probably does not come to mind, however, are the dried white beans in your kitchen pantry, the

I Saw This Cartoon Gumshoe Shooter in Action. It's a Video Game Miracle

Mouse: P.I. for Hire is the kind of fun video game miracle of making wild ideas into reality. What started as a throwaway "what if" post on social media about a first-person shooter styled like a classic Betty Boop-era cartoon has turned into a full video game I saw being played in front of me at Summer Game Fest -- and the gumshoe gunplay game is due out later this year. In Australian publisher PlaySide's private booth tucked into a corner of the Summer Game Fest grounds in Los Angeles, I sat

I Saw Mouse: P.I. for Hire Gameplay: It's Got Cartoon Gumshoe Gunplay Aplenty

Mouse: P.I. for Hire is the kind of fun video game miracle of making wild ideas into reality. What started as a throwaway "what if" post on social media about a first-person shooter styled like a classic Betty Boop-era cartoon has turned into a full video game I saw being played in front of me at Summer Game Fest that's due out later this year. In Australian publisher PlaySide's private booth tucked into a corner of the Summer Game Fest grounds in Los Angeles, I sat down with the game's lead pr

There's more to Mouse: PI for Hire than cartoon violence

Mouse: PI for Hire is a lot deeper than I initially assumed. When the game first caught buzz in May 2023 with an early teaser populated by placeholder assets, I didn’t understand the hype. The art style was definitely cool — Mouse is a black-and-white first-person shooter inspired by 1930s rubber hose cartoons, featuring bipedal rodents dressed like mobsters — but without any information about the gameplay loop, mechanics or narrative direction, I remained unmoved. After seeing Mouse in action

This New Drug Could Help End the HIV Epidemic—but US Funding Cuts Are Killing Its Rollout

After a lifetime on the frontiers of the fight against HIV, Linda-Gail Bekker could finally see the end of the epidemic in sight. For decades, HIV experts had dreamed of an elusive vaccine to block the ongoing chain of infections, which still sees more than 1 million people worldwide contract the virus annually. Bekker, a 62-year-old medical professor from the University of Cape Town, had helped identify a drug that could do just that. But now, thanks to the Trump administration’s executive ord