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Scientists are engineering particle-based delivery systems intended to ferry large molecules such as proteins and messenger RNA past the blood-brain barrier, a membrane that normally blocks such compounds from reaching brain tissue. Small chemicals like paracetamol already pass through naturally, but bigger therapeutic molecules cannot, limiting treatment options for brain disorders.
Researchers at the University of Minnesota, led by surgeon Daniel Saltzman, have developed a therapy using genetically modified Salmonella Typhimurium bacteria to carry interleukin-2, an immune-stimulating molecule, straight into tumours. Pancreatic cancer patient John Heller received the experimental treatment after starting chemotherapy for advanced disease, illustrating an early real-world test of the approach.
A Nature feature surveys six novel approaches under development for delivering drugs more precisely and effectively, ranging from advanced nanoparticle carriers to devices designed to target specific tissues. These innovations aim to overcome longstanding challenges such as poor bioavailability, degradation before reaching target sites, and off-target side effects.
A new speculative fiction piece from Nature Futures follows Melba, an employee managing the Lost Luggage Department at a nearly abandoned interstellar flight headquarters. The story details how travelers' bags are shrunk via molecular-reduction technology before space voyages, and how some end up misrouted for decades, eventually landing in Melba's basement office filled with stacks of miniaturized suitcases.
Google DeepMind's Demis Hassabis proposed training a large language model only on scientific knowledge available before 1911 to see if it could independently derive general relativity, calling it a meaningful test for artificial general intelligence. Several research teams, including one led by Ido Kaminer at Technion, have since built such 'vintage' AI models restricted to historical data, but early results have exposed shortcomings in current systems rather than demonstrating breakthrough reasoning.
Major employers including Accenture, Disney, Meta, JP Morgan, KPMG and Coinbase are now measuring staff AI adoption through leaderboards, training mandates and performance reviews, with some firms firing employees who don't comply. Accenture's CEO has openly stated that career advancement now depends on integrating AI into daily work, while a US consultancy executive describes unofficial pressure to show AI fluency to avoid being sidelined.
Google has signaled it will scale back certain search functionality for European users rather than fully comply with EU antitrust rules, aiming to sidestep potential fines. The company frames this as a response to regulatory demands it considers overly burdensome or conflicting with its business model.
Corning shares jumped 8% after announcing a multibillion-dollar partnership with Verizon to build fiber-optic cables for AI data centers, extending its 2025 gain to 90%. Qualcomm also rose after disclosing it issued Amazon warrants worth up to $4 billion in stock as part of a deal where AWS will buy up to $60 billion in Qualcomm server chips, with revenue starting in the December quarter. The news lifted other AI infrastructure stocks including Intel, AMD, HPE and Coherent.
The NSA, CISA, and FBI issued a joint advisory alleging that Chinese AI companies, including DeepSeek and Moonshot AI, have run large-scale campaigns since 2024 to extract capabilities from leading US models like ChatGPT, Claude, Gemini, and Grok. The agencies say these firms used millions of queries routed through multiple accounts, APIs, proxies, and cloud providers to generate synthetic training data and build competing models such as DeepSeek's R1/R3 and Moonshot's Kimi-K2/K3.
Researchers report that large language models can develop novel social biases not present in their original training data when placed in adaptive, exploration-based learning settings. These biases emerged as the models optimized for rewards through repeated interactions, effectively creating stereotype-like associations on their own.
Google has rolled out a fix for a glitch that left some YouTube users seeing missing thumbnails and YouTube TV users staring at fully blacked-out screens. The company confirmed the issue, which mainly hit users in Texas, is now resolved after previously suggesting a workaround of switching internet connections.
Workers' rights group LaborLab has released new tools letting employees see which consultants and law firms their employers hire to resist unionization efforts, and how much money is being spent. The launch highlights a roughly $1.7 billion industry of union avoidance specialists that, per Labor Department data, about 75% of employers rely on when facing organizing drives.