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Researchers led by Foschi and colleagues, publishing in Nature, developed an artificial-intelligence algorithm called kine that reconstructs continuous, movie-like views of relativistic plasma jets from black holes using sparse observational data. These jets, which blast material at over 98% of the speed of light, have historically been studied only through isolated snapshots, making it hard to trace their evolution over time.
Researchers extracted high molecular weight DNA from 15 sperm samples donated by 13 men from the TwinsUK cohort and an external biobank, using a modified extraction protocol designed to break down the tightly packed protamine structure of sperm DNA. Applying long-read sequencing to these samples, the team identified evidence of gene conversion occurring before meiosis, a genetic recombination process not previously well characterized at this resolution in sperm cells.
Researchers used a dual-site two-photon microscope to simultaneously track pons-projecting premotor cortical neurons (L5PTs) and cerebellar granule cells (GrCs) across mice performing two different tasks, virtual reality navigation and a reaching task. They found both cell types could be reliably tracked across days and contexts, with granule cell activity patterns reorienting cortical population trajectories to keep the two behavioral contexts distinct.
Researchers solved eight cryo-EM structures of human UGCG, the enzyme that gatekeeps glycosphingolipid synthesis, capturing it alone and bound to substrates, products and the drugs miglustat, ibiglustat and eliglustat. The team also ran molecular dynamics simulations and a cross-species sequence comparison spanning platypus, marsupials, elephants and other mammals to trace how UGCG regulation evolved, finding features unique to primates. All structural data, simulation files and sequences have been deposited in public repositories.
A referenced body of neuroscience research outlines how endocannabinoid molecules act as retrograde messengers, traveling backward across synapses to modulate neurotransmitter release. The compiled citations trace decades of work from the discovery of cannabinoid receptors to recent findings on how this signaling system shapes motivation and reward-seeking behavior.
Researchers developed an imaging method called kine that turns interferometric radio telescope measurements into dynamic video reconstructions rather than static snapshots. The technique relies on a neural field representation of a source's changing brightness distribution and was tested extensively on synthetic datasets before comparison with the established CLEAN method on real observations.
Researchers compiled river chemistry data from basaltic watersheds worldwide to recalculate how much carbon dioxide is naturally absorbed through silicate rock weathering. They found that critical zone processes—such as atmospheric deposition, hydrothermal contamination and secondary mineral formation—reduce the alkalinity that actually reaches rivers, meaning basalt weathering contributes a smaller share of global CO2 drawdown than prior estimates suggested, roughly 0.3% of annual anthropogenic emissions.
Researchers designed a chemical strategy that links a targeting molecule's binding action directly to the release of an anticancer payload, rather than relying solely on enzymatic cleavage. The team synthesized and validated compounds targeting fibroblast activation protein (FAP) and other markers, testing reaction rates and specificity using UPLC-mass spectrometry and antibody-based assays on proteins including PD-L1, DPPIV, and cathepsin B.
Scientists modeled how Mars' gravity field shifts over time due to solar tides, using a technique that lets gravity harmonic coefficients vary periodically at annual, semi-annual and other frequencies within orbit-determination software. By tracking these small periodic gravity variations, they detected a thermal anomaly located beneath the boundary separating Mars' northern lowlands and southern highlands, known as the crustal dichotomy.
Scientists grew high-purity single-crystal CrSb using chemical vapour transport and confirmed its structure through X-ray diffraction, resistivity, magnetization and Laue measurements. Using these bulk-resolved samples, they identified a three-dimensional g-wave altermagnetic order parameter in the material, characterizing how its magnetic symmetry differs from conventional magnets.
Malva is a search system that lets scientists query massive single-cell and spatial transcriptomic datasets using gene names, DNA sequences, or plain-language descriptions like 'cells expressing markers of neurodegeneration.' It combines a language model, a k-mer-based search index, and a metadata service to return annotated cell results in formats compatible with common analysis tools such as scanpy.
This bibliography compiles foundational studies establishing systems vaccinology, a field using genomics and machine learning to predict and understand vaccine-induced immunity in humans. Key cited works include the 2009 study by Querec and colleagues, which first showed that blood transcriptional signatures could predict antibody responses to the yellow fever vaccine, and related papers on multilineage immune activation and pandemic vaccine response variability.