Researchers modeled a cerebellum-like neural circuit to examine how a class of interneurons, called MG cells, influence the ability of ON and OFF output neurons to cancel predictable self-generated sensory signals, using an electric organ discharge mimic as the test stimulus. They found that the selectivity of synaptic connections—whether MG cells act mainly on broad spikes versus equally on broad and narrow spikes—determines whether these cells help or hinder the cancellation process.
Scientists isolated cells from developing human cortex tissue between 15 and 24 weeks gestation, fixing and preserving them for later analysis. They then used fluorescence-activated cell sorting with antibody markers like SOX2, EOMES, HOPX, OLIG2 and PU.1 to separate specific cell populations, including radial glia and oligodendrocyte precursor/microglial cells, for downstream genomic study.
Researchers used long-read direct RNA sequencing on Oxford Nanopore's PromethION platform to identify chimeric messenger RNAs—transcripts formed by joining sequences from two different genes—in mammalian immune cells. The study found that some of these hybrid transcripts are not just sequencing artifacts but actually get translated into functional proteins that play roles in immunity.
Nature's audio long read examines growing scientific evidence that unrepaired or poorly repaired DNA damage drives many hallmarks of ageing. Researchers are investigating whether artificially boosting the body's DNA repair mechanisms could extend healthy lifespan. The episode is an audio version of a Nature feature and is available on major podcast platforms.
The authors have retracted their paper on warming and global drought severity after discovering multiple errors, including failure to use area-weighted grid cells, inadvertent use of an outdated dataset (GLEAM v3 instead of GLEAM4), and a timestepping bug that misclassified data periods. They also acknowledged unclear explanations of how an arid-region mask was applied across different figures. Rather than issue a correction, the authors chose to retract the paper entirely and plan to resubmit a fully revised version for new peer review.
The authors of a study on B-cell selection thresholds in acute lymphoblastic leukaemia issued a correction after discovering an image duplication between Fig. 4d of this paper and Fig. 3l of another publication from the same research group. A separate duplication was also found within Extended Data Fig. 6e. Both figures have now been replaced with the correct original bioluminescence data and source files, including time stamps.
The journal has published an author correction to a study on endocannabinoids and reward engagement, updating the competing interests disclosure. The revised statement discloses that several authors are co-founders, board members, or the CEO of Biosyft, LLC, a company developing technologies related to the paper's subject matter. The correction applies to both the HTML and PDF versions of the article.
Researchers examined a fragment of 'hiroshimaite,' fallout material from the 1945 Hiroshima atomic bombing, and identified a previously unknown alloy composed of seven elements. The discovery, imaged via scanning electron microscope, was published in Science Advances ahead of the bombing's 81st anniversary.
A new United Nations Environment Programme report finds that current global emissions trends put the planet on track for roughly 1.8°C of warming above pre-industrial levels this century, effectively ending hopes of holding warming to the 1.5°C target set under the Paris Agreement. UNEP's executive director Inger Andersen acknowledged that countries have delayed climate action, failing to cut emissions at the pace scientists said was necessary.
Geophysicist Manoochehr Shirzaei of Virginia Tech found satellite imagery from days before the 26 August flash flood near the Nepal–Tibet border showing that a glacier section and underlying rock were accelerating in the weeks leading up to the collapse. The disaster, which killed more than 1,000 people and left over 4,000 missing, may have started with a rockslide dragging the glacier down or a glacier failure destabilizing the rocks; the exact sequence remains unclear.
Proper Dolby Atmos soundbar placement requires clearing obstructions like ceiling fans and light fixtures so upward-firing drivers can bounce sound cleanly off a flat ceiling. The soundbar should sit roughly halfway up the wall, parallel to seating and near ear level, while side-firing models need unobstructed wall reflections toward the couch. Smaller soundbars without up-firing drivers, such as the Sonos Beam, offer more flexible placement for compact spaces using virtual Atmos processing instead.
Snap is releasing its Specs smart glasses at a $2,195 price point, positioning the device as a major new consumer hardware product. CEO Evan Spiegel is pushing this bet even as Snap continues to face pressure over its lack of consistent profitability.
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