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What's going on with gene therapies?

news.ycombinator.com Nehal Udyavar 2025-07-20 06:48:53

Tree of Hope, Remain Strong (1946) by Frida Kahlo First attempts in a new field of medicine rarely go according to plan. On September 14, 1990, Dr. William French Anderson and his team at the National Institute of Health (NIH) performed the first official gene therapy trial. The patient, a 4-year-old Ashanti deSilva, suffered from a rare genetic disease called adenosine deaminase (ADA) deficiency, a form of severe combined immune deficiency (SCID). Children with ADA-SCID rarely make it to adult

Topics: cell cells gene months therapy

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All AI Models Might be The Same

news.ycombinator.com Jack Morris 2025-07-22 12:28:49

Project CETI is a large-scale effort to decode whale speech. If AI models do learn a universal language, we might be able to use it to talk to whales. Growing up, I sometimes played a game with my friends called “Mussolini or Bread.” It’s a guessing game, kind of like Twenty Questions. The funny name comes from the idea that, in the space of everything, ‘Mussolini’ and ‘bread’ are about as far away from each other as you can get. One round might go like this: Is it closer to Mussolini or bre

Topics: compression embedding model models representation

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Fighting AI with AI, finance firms prevented $5 million in fraud - but at what cost?

zdnet.com Webb Wright 2025-07-22 18:06:40

d3sign/Getty Imageds When most people think of AI, the first thing that probably comes to mind isn't superintelligence or the promise of agents to boost productivity, but scams. There've always been fraudsters among us, that small percentage of the population who'll use any means available to swindle others out of their money. The proliferation of advanced and easily accessible generative AI tools in recent years has made such nefarious activity exponentially easier. Also: Meet ChatGPT agent,

Topics: ai financial fraud tools use

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What's going on with gene therapies? (Part one)

news.ycombinator.com Nehal Udyavar 2025-07-20 16:48:53

Tree of Hope, Remain Strong (1946) by Frida Kahlo First attempts in a new field of medicine rarely go according to plan. On September 14, 1990, Dr. William French Anderson and his team at the National Institute of Health (NIH) performed the first official gene therapy trial. The patient, a 4-year-old Ashanti deSilva, suffered from a rare genetic disease called adenosine deaminase (ADA) deficiency, a form of severe combined immune deficiency (SCID). Children with ADA-SCID rarely make it to adult

Topics: cell cells gene months therapy

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How to run an LLM on your laptop

technologyreview.com Grace Huckins 2025-07-22 22:01:29

For Pistilli, opting for local models as opposed to online chatbots has implications beyond privacy. “Technology means power,” she says. “And so who[ever] owns the technology also owns the power.” States, organizations, and even individuals might be motivated to disrupt the concentration of AI power in the hands of just a few companies by running their own local models. Breaking away from the big AI companies also means having more control over your LLM experience. Online LLMs are constantly sh

Topics: llms local model models run

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Google hides secret message in name list of 3,295 AI researchers

arstechnica.com Unknown 2025-07-22 22:12:01

How many Google AI researchers does it take to screw in a lightbulb? A recent research paper detailing the technical core behind Google's Gemini AI assistant may suggest an answer, listing an eye-popping 3,295 authors. It's a number that recently caught the attention of machine learning researcher David Ha (known as "hardmaru" online), who revealed on X that the first 43 names also contain a hidden message. "There’s a secret code if you observe the authors’ first initials in the order of author

Topics: ai authors gemini google models

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Researchers from OpenAI, Anthropic, Meta, and Google issue joint AI safety warning - here's why

zdnet.com Radhika Rajkumar 2025-07-23 10:15:39

Andriy Onufriyenko / Getty Images Over the last year, chain of thought (CoT) -- an AI model's ability to articulate its approach to a query in natural language -- has become an impressive development in generative AI, especially in agentic systems. Now, several researchers agree it may also be critical to AI safety efforts. On Tuesday, researchers from competing companies including OpenAI, Anthropic, Meta, and Google DeepMind, as well as institutions like the Center for AI Safety, Apollo Resea

Topics: ai cot model models researchers

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Adobe Firefly can now generate sound effects from your audio cues

engadget.com Unknown 2025-07-23 14:00:08

Since rolling out the redesign of its Firefly app in April, Adobe has been releasing major updates for the generative AI hub at a near monthly clip. Today, the company is introducing a handful of new features to assist those who use Firefly's video capabilities. To start, Adobe is making it easier to add sound effects to AI-generated clips. Right now, the majority of video models create footage without any accompanying audio. Adobe is addressing this with a nifty little feature that allows user

Topics: adobe firefly models sound video

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EU presses pause on probe of X as US trade talks heat up

arstechnica.com Unknown 2025-07-23 14:19:05

The European Commission has stalled one of its investigations into Elon Musk’s X for breaking the bloc’s digital transparency rules, while it seeks to conclude trade talks with the US. Brussels was expected to finalise its probe into the social media platform before the EU’s summer recess but will miss this deadline, according to three officials familiar with the matter. They noted that a decision was likely to follow after clarity emerged in the EU-US trade negotiations. “It’s all tied up,” on

Topics: bloc brussels eu percent trade

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Slack is getting a host of new AI tools

engadget.com Unknown 2025-07-23 18:00:23

Slack, the cloud‑based team messaging juggernaut, is charging ahead with further integration of AI into users’ day‑to‑day experience. The company is introducing a series of tools aimed at improving productivity and improving team communication. AI writing assistance has been built directly into Slack Canvas, allowing users to create assets like project briefs as well as refine the content they create using natural‑language prompts. Writing assistance can also be used to generate and assign acti

Topics: ai assistance slack tools users

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Best T-Mobile Plans: How to Choose and Which Ones to Pick in 2025

cnet.com See Full Bio 2025-07-23 17:00:00

The T-Mobile Essentials Saver plan offers unlimited data usage and includes 50GB of "Premium" data, which is the fastest-capable 5G rate available in your area. After 50GB, speeds are reduced to 3G levels for the remainder of the month. However, that Premium may not always be so premium: T-Mobile notes in the fine print that "Essentials customers may notice speeds lower than other customers and further reduction if using >50GB/month, due to data prioritization." You can use your phone as a mobi

Topics: data essentials mobile plan saver

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All the Best Places We Can Stream Free Anime, Every Day

cnet.com See Full Bio 2025-07-23 17:00:11

July is anime month, but that doesn't mean paying for streaming subscriptions is always in the budget, right? Some of you may have read the headline on this and thought your anime piracy wishes were about to come true. Sorry friends, this isn't the place where we'll point you to bootleg anime. What we can do, however, is highlight the streaming platforms that give you free content aside from Crunchyroll's free plan. In this case, FAST options are the way to go. Classics like One Piece, Sailor M

Topics: anime channel channels like tv

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I take this $30 pocket multitool everywhere, and keep finding new uses for it

zdnet.com Adrian Kingsley-Hughes 2025-07-24 00:45:11

ZDNET's key takeaways The NexTool Pocket Tool E1 is a premium pocket tool for under $30. All the tools are nice and sharp when new, and retain their sharpness even after extended use. Because this is a pocket tool, don't expect pliers or a lifetime warranty. View now at Walmart View now at Amazon more buying choices I've been a big fan of multitools and pocket tools for decades. I've owned several items from big names like Leatherman, Gerber, and Victorinox. Some I still have, others I've giv

Topics: multitool pocket tool tools ve

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I Got a Cortisol Blood Test. What I Learned About My Stress Was Important, but Not Fun

cnet.com See Full Bio 2025-07-24 01:17:03

Historically, I haven't been great about managing my stress and anxiety, so whenever I come across a video or article about cortisol imbalances, my interest is piqued. Since cortisol is also called the "stress hormone," this content has made me wonder: Is my stress causing my cortisol levels to rise? Though I was nervous, I decided to take Quest's Cortisol Blood Stress Hormone Test, which was offered to me for free, to find out more. After my cortisol blood test, I had a lot of residual questio

Topics: blood cortisol levels stress test

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Microsoft is saving millions with AI and laying off thousands - where do we go from here?

zdnet.com Radhika Rajkumar 2025-07-24 04:00:14

Drew Angerer/Getty Images Last week, Bloomberg reported that Microsoft shared internally that it had saved $500 million in call center costs, thanks to AI -- shortly after the company laid 9,000 people off, the third round in a series of layoffs totaling 15,000. What does this mean for the tech industry -- and job security for humans -- at large? Also: 60% of managers use AI to make decisions now, including whom to promote and fire - does yours? Microsoft's layoffs, despite huge profits Acc

Topics: ai companies microsoft tools workers

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Remembrance of Scents Past

news.ycombinator.com Margaret Talbot 2025-07-22 04:03:27

But Marks argues that smell is one of the most potent ways to give museum visitors a visceral sense of the past, and to help them remember what they read or saw in an exhibit. Among the scents she designed for the docks exhibition was one inspired by a woman’s memory, in the oral histories, of her dockworker father’s damp woollen coat drying on an electric fire in the nineteen-sixties. Marks thought that the coat might have smelled like her own grandfather’s wool flat cap. He’d been a London cab

Topics: like marks scent smell smells

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A recap on May/June stability at Neon

news.ycombinator.com Nikita Shamgunov 2025-07-24 03:22:57

Details of incidents and what we did to prevent more in the future Starting in May, we had a series of feature launches with agentic AI partners that gained far more momentum than we predicted. In two short timespans, the rate of new database creation increased more than 5x, and the rate of branch creation increased more than 50x. While we were humbled by the uptick, the significant burst in operational load caused a lot of strain in the Neon platform, manifesting as more incidents over the cou

Topics: cells database databases incidents project

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A Recap on May/June Stability at Neon

news.ycombinator.com Nikita Shamgunov 2025-07-24 13:22:57

Details of incidents and what we did to prevent more in the future Starting in May, we had a series of feature launches with agentic AI partners that gained far more momentum than we predicted. In two short timespans, the rate of new database creation increased more than 5x, and the rate of branch creation increased more than 50x. While we were humbled by the uptick, the significant burst in operational load caused a lot of strain in the Neon platform, manifesting as more incidents over the cou

Topics: cells database databases incidents project

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OpenAI, Google, and Meta Researchers Warn We May Lose the Ability to Track AI Misbehavior

gizmodo.com Rhett Jones 2025-07-24 22:05:11

Over 40 scientists from the world’s leading AI institutions, including OpenAI, Google DeepMind, Anthropic, and Meta, have come together to call for more research in a particular type of safety monitoring that allows humans to analyze how AI models “think.” The scientists published a research paper on Tuesday that highlighted what is known as chain of thought (CoT) monitoring as a new yet fragile opportunity to boost AI safety. The paper was endorsed by prominent AI figures like OpenAI co-founde

Topics: ai cot models researchers safety

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The Big Beautiful Bill Is Bad for Americans’ Health and Wallets, Study Finds

gizmodo.com Ed Cara 2025-07-24 22:42:42

The “Big Beautiful Bill” is now law, and it’s poised to wreak plenty of destruction. Research out today finds that the policy changes will lead to thousands more deaths annually, as well as harm the financial health of rural hospitals. Epidemiologists at the University of California, San Francisco, and elsewhere conducted the study. They found the Medicaid cuts caused by the Big Beautiful Bill will cause many avoidable hospitalizations and deaths, put dozens of rural hospitals at high risk of c

Topics: changes coverage health hospitals medicaid

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Claude Code revenue jumps 5.5x as Anthropic launches analytics dashboard

venturebeat.com Michael Nuñez 2025-07-25 01:00:00

Want smarter insights in your inbox? Sign up for our weekly newsletters to get only what matters to enterprise AI, data, and security leaders. Subscribe Now Anthropic announced today it is rolling out a comprehensive analytics dashboard for its Claude Code AI programming assistant, addressing one of the most pressing concerns for enterprise technology leaders: understanding whether their investments in AI coding tools are actually paying off. The new dashboard will provide engineering managers

Topics: ai claude code enterprise tools

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OpenAI and Anthropic researchers decry ‘reckless’ safety culture at Elon Musk’s xAI

techcrunch.com Maxwell Zeff 2025-07-25 02:11:20

AI safety researchers from OpenAI, Anthropic, and other organizations are speaking out publicly against the “reckless” and “completely irresponsible” safety culture at xAI, the billion-dollar AI startup owned by Elon Musk. The criticisms follow weeks of scandals at xAI that have overshadowed the company’s technological advances. Last week, the company’s AI chatbot, Grok, spouted antisemitic comments and repeatedly called itself “MechaHitler.” Shortly after xAI took its chatbot offline to addre

Topics: ai grok models safety xai

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Top AI Researchers Concerned They’re Losing the Ability to Understand What They’ve Created

futurism.com Unknown 2025-07-25 05:15:31

Researchers from OpenAI, Google DeepMind, and Meta have joined forces to warn about what they're building. In a new position paper, 40 researchers spread across those four companies called for more investigation of AI powered by so-called "chains-of-thought" (CoT), the "thinking out loud" process that advanced "reasoning" models — the current vanguard of consumer-facing AI — use when they're working through a query. As those researchers acknowledge, CoTs add a certain transparency into the inn

Topics: ai models openai paper researchers

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AWS unveils Bedrock AgentCore, a new platform for building enterprise AI agents with open source frameworks and tools

venturebeat.com Emilia David 2025-07-25 10:31:56

Want smarter insights in your inbox? Sign up for our weekly newsletters to get only what matters to enterprise AI, data, and security leaders. Subscribe Now Cloud giant Amazon Web Services (AWS) believes AI agents will change how we all work and interact with information, and that enterprises need a platform that allows them to build and deploy agents at scale — all in one place. Today at its New York Summit, AWS unveiled Amazon Bedrock AgentCore, a new enterprise-grade platform designed to bu

Topics: agentcore agents ai aws tools

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Mkosi – Build Bespoke OS Images

news.ycombinator.com Unknown 2025-07-25 10:14:20

mkosi — Build Bespoke OS Images A fancy wrapper around dnf --installroot , apt , pacman and zypper that generates customized disk images with a number of bells and whistles. Documentation Contributing Tutorials Project

Topics: apt bells bespoke contributing images

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The First Trailer for ‘Hoppers’ Wants to Be ‘Avatar’ With Beavers

gizmodo.com Sabina Graves 2025-07-25 10:35:56

Pixar‘s animal kingdom and sci-fi mash-up, Hoppers, just dropped a hilarious first look fleshing out its premise, which asks, “What if we could finally talk to animals?” The trailer introduces a tech breakthrough in the form of a robot animal that scientists manage to transfer anyone’s brain into in order to get in deep with other species. And yeah, it’s like James Cameron’s Avatar, but make it cute. Our Sully in this case is Mabel (Piper Curda), who lets her mind hop into the tech prototype an

Topics: animal animals hoppers mabel pixar

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The 13-inch M2 MacBook Air is a great back-to-school deal at just $699

theverge.com Sheena Vasani 2025-07-25 10:43:19

It’s almost back to school season, and we’re starting to see some great laptop deals trickle in as a result. Walmart continues to sell the M1-powered MacBook Air for $599, but if you want more power and a sleeker design, the 13-inch M2-powered MacBook Air starts at just $699 ($100 off) from Best Buy. That’s its best price to date, and it’s available on the configuration that offers 256GB of storage and 16GB of RAM, double what’s in the base M1 model. The M2-powered MacBook Air remains an excell

Topics: air buds deals like macbook

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What Actually Happens When Programmers Use AI Is Hilarious, According to a New Study

futurism.com Unknown 2025-07-25 17:03:29

AI has taken the programming world by storm, with a flurry of speculation about the tech replacing human coders, and Google's CEO recently claiming that 25 percent of the company's code is now AI-generated. But it's possible that in practice, AI is actually hindering efficient software development. As flagged by Ars Technica, a new study from the nonprofit Model Evaluation and Threat Research (METR) found that in practice, programmers are actually slower when using AI assistance tools than maki

Topics: ai coding programmers time tools

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The AirPods 4 are still on sale at a near record low price

engadget.com Unknown 2025-07-25 18:16:31

Engadget has been testing and reviewing consumer tech since 2004. Our stories may include affiliate links; if you buy something through a link, we may earn a commission. Read more about how we evaluate products . Prime Day is no more, but you can still save on Apple’s earbuds. Prime Day might be behind us, but the dregs of the deals are still lingering. And if you’re in the market for a new pair of AirPods, you’re in luck. Apple’s ever-popular AirPods 4 (the ones without ANC) are currently dow

Topics: airpods anc apple day deals

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Crypto bounces on renewed optimism House could pass key stablecoin legislation this week

cnbc.com Tanaya Macheel 2025-07-26 02:29:19

In this article COIN CRCL ETH.CM= BTC.CM= Follow your favorite stocks CREATE FREE ACCOUNT Nurphoto | Nurphoto | Getty Images Cryptocurrencies and several stocks tied to the ecosystem rose Wednesday as investors dismissed a snag in what was expected to be a winning week for crypto regulation. Bitcoin was last higher by 2% at $119,114.79, according to Coin Metrics, while ether rose 3% to $3,156. Shares of stablecoin issuer Circle added more than 1% premarket and crypto services firm Coinbase

Topics: bills chart house stock stocks

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Latest Tech News

What's going on with gene therapies?

All AI Models Might be The Same

Fighting AI with AI, finance firms prevented $5 million in fraud - but at what cost?

What's going on with gene therapies? (Part one)

How to run an LLM on your laptop

Google hides secret message in name list of 3,295 AI researchers

Researchers from OpenAI, Anthropic, Meta, and Google issue joint AI safety warning - here's why

Adobe Firefly can now generate sound effects from your audio cues

EU presses pause on probe of X as US trade talks heat up

Slack is getting a host of new AI tools

Best T-Mobile Plans: How to Choose and Which Ones to Pick in 2025

All the Best Places We Can Stream Free Anime, Every Day

I take this $30 pocket multitool everywhere, and keep finding new uses for it

I Got a Cortisol Blood Test. What I Learned About My Stress Was Important, but Not Fun

Microsoft is saving millions with AI and laying off thousands - where do we go from here?

Remembrance of Scents Past

A recap on May/June stability at Neon

A Recap on May/June Stability at Neon

OpenAI, Google, and Meta Researchers Warn We May Lose the Ability to Track AI Misbehavior

The Big Beautiful Bill Is Bad for Americans’ Health and Wallets, Study Finds

Claude Code revenue jumps 5.5x as Anthropic launches analytics dashboard

OpenAI and Anthropic researchers decry ‘reckless’ safety culture at Elon Musk’s xAI

Top AI Researchers Concerned They’re Losing the Ability to Understand What They’ve Created

AWS unveils Bedrock AgentCore, a new platform for building enterprise AI agents with open source frameworks and tools

Mkosi – Build Bespoke OS Images

The First Trailer for ‘Hoppers’ Wants to Be ‘Avatar’ With Beavers

The 13-inch M2 MacBook Air is a great back-to-school deal at just $699

What Actually Happens When Programmers Use AI Is Hilarious, According to a New Study

The AirPods 4 are still on sale at a near record low price

Crypto bounces on renewed optimism House could pass key stablecoin legislation this week

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