Removing newlines in FASTA file increases ZSTD compression ratio by 10x
Zstandard's long range mode works wonders for genome sequences without newlines September 12, 2025 First released with Zstandard 1.3.2 in 2017, the --long range match finder increases the compressor’s search window to at least 128MiB, improving deduplication inside large files. This optional feature had substantial performance overheads at launch, but various optimisations have since brought its performance within shooting distance of Zstandard’s fast defaults. As a fan of Zstandard’s speed an