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Removing newlines in FASTA file increases ZSTD compression ratio by 10x

Zstandard's long range mode works wonders for genome sequences without newlines September 12, 2025 First released with Zstandard 1.3.2 in 2017, the --long range match finder increases the compressor’s search window to at least 128MiB, improving deduplication inside large files. This optional feature had substantial performance overheads at launch, but various optimisations have since brought its performance within shooting distance of Zstandard’s fast defaults. As a fan of Zstandard’s speed an

Microsoft is changing how Xbox controllers work on Windows 11

is a senior editor and author of Notepad , who has been covering all things Microsoft, PC, and tech for over 20 years. Posts from this author will be added to your daily email digest and your homepage feed. Microsoft has started testing a change to how Xbox controllers operate on Windows 11. The change will allow Xbox controllers to easily access the Task View on Windows 11 to tab between apps and games, using the Xbox button. “A new change we’re introducing is when you long press the Xbox bu

New VoidProxy phishing service targets Microsoft 365, Google accounts

A newly discovered phishing-as-a-service (PhaaS) platform, named VoidProxy, targets Microsoft 365 and Google accounts, including those protected by third-party single sign-on (SSO) providers such as Okta. The platform uses adversary-in-the-middle (AitM) tactics to steal credentials, multi-factor authentication (MFA) codes, and session cookies in real time. VoidProxy was discovered by Okta Threat Intelligence researchers, who describe it as scalable, evasive, and sophisticated. The attack begi

OCSP Service Has Reached End of Life

Today we turned off our Online Certificate Status Protocol (OCSP) service, as announced in December of last year. We stopped including OCSP URLs in our certificates more than 90 days ago, so all Let’s Encrypt certificates that contained OCSP URLs have now expired. Going forward, we will publish revocation information exclusively via Certificate Revocation Lists (CRLs). We ended support for OCSP primarily because it represents a considerable risk to privacy on the Internet. When someone visits a

After the Virtual Boy, There’s No Reason Why Nintendo Can’t Bring Back Its Best Handheld

Nintendo doesn’t normally let fans in on its hardware plans, but if you’re the type of person to spot trends, it’s clear the Switch 2 will become the Mario maker’s everything console. Nintendo has started offering more hardware specifically tailored for playing its old, defunct consoles. The inevitable next step is for the company to let us return to its most popular handheld ever, the Nintendo DS. Today, Nintendo decided it was time to bring back what is likely its least popular gaming hardwar

Presence in VR should show tiny people, not user avatars (2022)

Since picking up a virtual reality headset a couple weeks ago, I’ve been asking myself: how should the future operating system for apps work? Like: how do you write docs? How do you collaborate on a deck? How do you launch your messaging app? Games are easy because they get to be weird. But for apps you need standard behaviours. So I’m trying to think through this from first principles and see what comes to mind… ALSO keep in mind that I have become obsessed with the overview mode in Walkabou

Topics: app head like screen vr

Canelo vs. Crawford Fight: What Time to Watch the Action Tonight on Netflix

Saul "Canelo" Álvarez and Terence Crawford step into the ring tonight in a pro boxing matchup that will see Álvarez defending his title as super middleweight champion. As the crowd descends upon Las Vegas to watch the pair square up, the question lingers in the air of whether Crawford will beef up his weight -- and by how much -- to meet his opponent's. While Álvarez is a seasoned super middleweight contender (and current undisputed champion), Crawford has never fought in this weight class and

Hike, once a unicorn, shuts down as India cracks down on real-money gaming

Hike, once one of India’s most valuable startups with unicorn status, has become the latest casualty of New Delhi’s recent real-money gaming ban, with the company — led by Kavin Bharti Mittal, son of Airtel founder Sunil Bharti Mittal — now shutting down. On Saturday, Hike founder Mittal (pictured above) said that the startup’s U.S. business, which launched nine months ago, was “off to a strong start.” But he said scaling it globally would require “a full recap, a reset that is not the best use

Heroic Gas Station Clerk Realizes Elderly Women Are Being Scammed at the Bitcoin ATM, Unplugs It to Save Them

One of the core appeals of cryptocurrency — other than providing a get-rich-quick scheme for famous people with huge sway over their followers, like a sitting president or an airheaded influencer — is that it's decentralized and largely unregulated. Of course, that also makes it a breeding ground for fraud. Just ask Boise, Idaho gas station clerk Avalon Hardy. As Inc reports, she ended up repeatedly intervening to stop old ladies from getting ripped off by using the establishment's Bitcoin ATM

Tether Taps Trump’s Former Crypto Advisor to Lead US Operations

In an effort to solidify itself as the go-to company in the cryptocurrency space for stablecoins, Tether is tapping Bo Hines, the former Executive Director of Donald Trump’s White House Crypto Council to lead its operations in the United States, including efforts to launch a new stablecoin called USAT that will comply with new, Trump-backed regulations, according to CNBC. Tether is best known for its USDT stablecoin, which is pegged to the US Dollar and has become the most commonly used token f

All-around protection: ESR launches iPhone 17 cases, screen protectors, AirPods covers

Following Apple’s ‘Awe Dropping’ event yesterday, ESR is unveiling a comprehensive lineup of accessories, cases, screen protectors, and chargers that will help you unleash the full power of your new devices, keeping them safe and powered up. iPhone 17 cases ESR’s flagship launch for the season exceeds military-grade standards by 7x, and starts at $26.99. In practice, this means the ESR Cyber Tough Magnetic Case is tough enough to handle 23-ft (7m) drops, thanks in part to its reinforced Air G

Canelo vs. Crawford: When to Watch the Fight Live on Netflix

Pro boxers Saul "Canelo" Álvarez and Terence Crawford are heading into a weekend match that will see Álvarez defending his title as super middleweight champion. As the crowd descends upon Las Vegas to watch the pair square up, the question lingers in the air of whether Crawford will beef up his weight -- and by how much -- to meet his opponent's. While Álvarez is a seasoned super middleweight contender (and current undisputed champion), Crawford has never fought in this weight class and planned

First 'perovskite camera' can see inside the human body

Physicians rely on nuclear medicine scans, like SPECT scans, to watch the heart pump, track blood flow and detect diseases hidden deep inside the body. But today’s scanners depend on expensive detectors that are difficult to make. Now, scientists led by Northwestern University and Soochow University in China have built the first perovskite-based detector that can capture individual gamma rays for SPECT imaging with record-breaking precision. The new tool could make common types of nuclear medic

Modder injects AI dialogue into 2002’s Animal Crossing using memory hack

When software engineer Joshua Fonseca recently connected the GameCube simulation classic Animal Crossing to a modern AI language model like the kind that powers ChatGPT, he decided to shake things up. By programming the AI to roleplay as villagers growing aware of their debt situation, and giving them a shared memory to track conversations, Fonseca orchestrated a scenario where the residents began to organize against their raccoon landlord. In Animal Crossing, Tom Nook runs the town shop and pr

Microsoft Offers Windows 10 Extended Security Updates for Free. You Just Need to Do One Thing

Microsoft is sunsetting Windows 10 support on Oct. 14, and with it stopping all updates to the former OS. If you aren't able to update to Windows 11, you still have options. For $30 you can grab a year of extended-security updates. There is also a free option available, provided you're willing to enable cloud backup and connect it to your OneDrive account. The ability to get free updates on Windows 10 is a pretty big deal because it is still the most widely used Windows OS, accounting for just

Microsoft Will Lower Price of Office 365 Without Teams Platform, Avoiding EU Antitrust Fine

Microsoft has agreed to sell Office 365 suites unbundled without Teams for a significantly lower price than previously, ending a five-plus-year European Union dispute with Slack and avoiding a fine by the EU. The software giant was charged with EU antitrust violations in June 2024 for bundling Teams with Office 365 and Microsoft 365 subscriptions. The dispute began in July 2020, when Slack (now owned by Salesforce) filed an official complaint, alleging Microsoft was conducting an "illegal and a

Apple Watch Fans Get a Much-Needed Upgrade With the Ultra 3

If you're more comfortable hiking mountain trails or gliding under water, or you just prefer a chunky smartwatch with days of battery life, your patience over the last couple of years has paid off. At Tuesday's big fall event, Apple officially announced the Apple Watch Ultra 3, the next generation of Apple's high-performance smartwatch. The Ultra 3 adds a brighter, larger display, 5G cellular communication, satellite connectivity, a battery life increase of up to 42 hours and the ability to det

Windows 11 23H2 Home and Pro reach end of support in 60 days

Microsoft has reminded customers today that devices running Home and Pro editions of Windows 11 23H2 will stop receiving updates in November. Enterprise and Education editions will continue to receive mainstream support for an additional year, until November 10, 2026, as stated on the Windows release health dashboard. "On November 11, 2025, Windows 11, version 23H2 (Home and Pro editions) will reach end of servicing. The November 2025 monthly security update will be the last update available f

New HybridPetya ransomware can bypass UEFI Secure Boot

A recently discovered ransomware strain called HybridPetya can bypass the UEFI Secure Boot feature to install a malicious application on the EFI System Partition. HybridPetya appears inspired by the destructive Petya/NotPetya malware that encrypted computers and prevented Windows from booting in attacks in 2016 and 2017 but did not provide a recovery option. Researchers at cybersecurity company ESET found a sample of HybridPetya on VirusTotal. They note that this may be a research project, a p

Micro1, a competitor to Scale AI, raises funds at $500M valuation

Micro1, a three-year-old startup that helps AI companies find and manage human contractors for data labeling and training, has raised a $35 million Series A funding round that values the company at $500 million. The round was led by O1 Advisors, a venture capital firm co-founded by Dick Costolo and Adam Bain, the former CEO and COO of Twitter. The startup is one of many companies looking to fill the gap in the data market created by recent changes involving Scale AI. After Meta invested $14 bil

Crates.io phishing attempt

crates.io phishing attempt Sep 12, 2025 1 min Earlier this week, an npm supply chain attack. It’s turn for crates.io, the main public repository for Rust crates (packages). The phishing e-mail looks like this: And it leads to a GitHub login page that looks like this: Several maintainers received it — the issue is being discussed on GitHub. The crates.io team has acknowledged the attack and said they’d see if they can do something about it. No compromised packages have been identified as

Topics: 12 crates github io looks

Physicists Made a Time Crystal We Can Actually See

Of all the eccentricities of the quantum realm, time crystals—atomic arrangements that repeat certain motions over time—might be some of the weirdest. But they certainly exist, and to provide more solid proof, physicists have finally created a time crystal we can actually see. In a recent Nature Materials paper, physicists at the University of Colorado Boulder presented a new time crystal design: a glass cell filled with liquid crystals—rod-shaped molecules stuck in strange limbo between solid

I Tested iOS 26 for 3 Months and Liquid Glass Isn't the Only Game-Changing Feature

CNET’s expert staff reviews and rates dozens of new products and services each month, building on more than a quarter century of expertise. Apple/ Zooey Liao/ CNET The wait is almost over. Apple is set to release iOS 26 on Monday. It's been three months since the company announced the software update at the Worldwide Developers Conference in June, with the first beta version released shortly after. Since then, I've been living with the beta software on two iPhones: my iPhone 16 Pro and 14 Pro

Topics: 26 apple ios like screen

This is the Most Effective Type of Creatine You Should Be Taking to See Results, According to Registered Dietitians

If you look in the supplement aisle at your local pharmacy, you'll likely find different forms of creatine in gummies, powders, capsules and even drink mixes. That's because creatine is a popular fitness supplement for those who want to gain strength and power while improving performance. It's also naturally made in our bodies and assists our muscles with energy production when we work out. Though creatine can be found in smaller quantities in foods like salmon, chicken, beef and pork, many peo

Crates.io Phishing Attempt

crates.io phishing attempt Sep 12, 2025 1 min Earlier this week, an npm supply chain attack. It’s turn for crates.io, the main public repository for Rust crates (packages). The phishing e-mail looks like this: And it leads to a GitHub login page that looks like this: Several maintainers received it — the issue is being discussed on GitHub. The crates.io team has acknowledged the attack and said they’d see if they can do something about it. No compromised packages have been identified as

Topics: 12 crates github io looks

Last day to amplify your brand: Host your Side Event at TechCrunch Disrupt 2025

The countdown is on: The application to host a Side Event at TechCrunch Disrupt 2025 closes tonight at 11:59 p.m. PT. If you’ve been considering a way to amplify your brand during the week’s tech epicenter, now is the time to lock it in. Your Side Event could be the dinner everyone’s still talking about, the panel that sparks a deal, or the happy hour that launches a new collaboration. With 10,000+ Disrupt attendees in San Francisco — plus the global spotlight of TechCrunch promotion — your e

Active phishing campaign targeting crates.io users

We received multiple reports of a phishing campaign targeting crates.io users (from the rustfoundation.dev domain name), mentioning a compromise of our infrastructure and asking users to authenticate to limit damage to their crates. These emails are malicious and come from a domain name not controlled by the Rust Foundation (nor the Rust Project), seemingly with the purpose of stealing your GitHub credentials. We have no evidence of a compromise of the crates.io infrastructure. We are taking s

The best laptops under $1,000 of 2025: Expert tested and reviewed

People tend to equate concepts like "budget" or "low-cost" with poor quality, but that's not true. You can find plenty of high-quality laptops that cost less than $1,000. I'm talking about well-crafted, powerful computers that can compete with the best laptops on the market when tackling productivity and entertainment workloads. It certainly helps that many budget laptops were former high-end devices. Apple, for example, frequently drops the price of older MacBooks whenever a new one comes out.

Is Your Gut in Trouble? 5 Warning Signs You Shouldn't Ignore

The trillions of microbes that live in your gut are likened to "little pets living inside your intestinal tract." Or at least, that's how Gail Cresci, a microbiome expert at the Cleveland Clinic, describes it. But they do far more than help digest food. They also support your immune system, regulate inflammation, and produce essential compounds like vitamins and hormones that keep your body running smoothly. Because your gut plays such a big role in your overall health, it's important to recogn