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New treatment eliminates bladder cancer in 82% of patients

news.ycombinator.com Unknown 2025-12-05 00:16:59

TAR-200 is a miniature, pretzel-shaped drug-device duo containing a chemotherapy drug, gemcitabine, which is inserted into the bladder through a catheter and releases the drug for three weeks per treatment cycle. How the drug delivery system works TAR-200 is a miniature, pretzel-shaped drug-device duo containing a chemotherapy drug, gemcitabine, which is inserted into the bladder through a catheter. Once inside the bladder, the TAR-200 slowly and consistently releases the gemcitabine into the

Topics: 200 bladder cancer drug patients

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OpenIndiana: Community-Driven Illumos Distribution

news.ycombinator.com Unknown 2025-12-05 00:23:15

OpenIndiana Hipster 2021.04 is here After another 6 months have passed, we are proud to announce the release of our 2021.04 snapshot. The images are available at the usual place. As usual we have automatically received all updates that have been integrated into illumos-gate. This release’s most notably changes are ... Click to Read more

Topics: 04 2021 available release usual

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Leaky Ice Dam Prompts Evacuations in Alaska as Record Floods Loom

gizmodo.com Margherita Bassi 2025-12-05 00:10:41

A water basin in Alaska is overflowing its ice dam, the Mendenhall Glacier, and flooding the state capital, Juneau. Experts expect the likely record-breaking event to peak today, and officials have asked residents in parts of the city and borough to evacuate. The flood doesn’t come as a surprise. Years ago, a small glacier on the other side of Mendenhall Glacier—which is just 12 miles (19 kilometers) from Juneau—receded and left a basin in its wake, according to the Associated Press. Since then

Topics: alaska basin flood glacier mendenhall

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The HORI Piranha Plant camera for Nintendo Switch 2 is on sale for 33 percent off

engadget.com Unknown 2025-12-05 04:56:27

Even though the Switch 2 basically just came out, we're already starting to see discounts on some of its accessories. One of the more charming peripherals, the HORI Piranha Plant camera, is on sale right now for only $40. That's $20 off and a record-low price. It's a good deal for anyone who wants to take advantage of the Switch 2's camera functionality in games like Mario Kart World and that recently-released campfire sim. This was designed specifically for Nintendo's new console, so it's a pl

Topics: camera kart piranha plant switch

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I tried Lenovo's $3,000 rollable ThinkBook and can't go back to regular-sized screens

zdnet.com Kyle Kucharski 2025-12-05 05:19:00

ThinkBook Plus Gen 6 Rollable ZDNET's key takeaways The ThinkBook Plus Gen 6 is available now, starting at $3,300. The 120Hz, OLED, portrait-style 16.7-inch display delivers an expansive workspace, supported by a haptic touchpad. It has limited I/O, has some visible creasing on the rollable display, and has a sky-high price. View now at Lenovo Lenovo unveiled its "rollable" laptop at CES two years ago as a wild proof of concept that turned heads, but left consumers skeptical. Well, the compan

Topics: display laptop lenovo rollable screen

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This is the fastest local AI I've tried, and it's not even close - how to get it

zdnet.com Jack Wallen 2025-12-05 05:52:00

Jack Wallen / Elyse Betters Picaro / ZDNET ZDNET's key takeaways The gpt-oss:20b model is very fast. You'll get blazing-fast answers to your queries with gpt-oss:20b. With the latest version of Ollama installed, you can use this model. Let's talk about local AI and speed. There are a lot of factors that go into getting the most speed out of your AI, such as: Whether you have a dedicated GPU. The context length you use (the smaller, the faster). The complexity of your query. The LLM you

Topics: 20b gpt ollama oss use

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Pebble Time 2 Design Reveal [video]

news.ycombinator.com Unknown 2025-12-05 03:54:45

No Content Available

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Study: Social media probably can’t be fixed

arstechnica.com Unknown 2025-12-05 05:32:58

Ars Technica: I was frankly surprised at the ineffectiveness of the various intervention strategies you tested. But it does seem to explain the Bluesky conundrum. Bluesky has no algorithm, for example, yet the same dynamics still seem to emerge. I think Bluesky's founders genuinely want to avoid those dysfunctional issues, but they might not succeed, based on this paper. Why are such interventions so ineffective? Petter Törnberg: We've been discussing whether these things are due to the platfor

Topics: bluesky doesn interventions platforms want

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Hands-on: We ran full desktop Linux apps on an Android phone!

androidauthority.com Unknown 2025-12-05 10:00:16

Mishaal Rahman / Android Authority TL;DR An upcoming Android update will significantly upgrade the Linux Terminal app, enabling it to run full-fledged graphical Linux programs on supported devices. The feature is currently experimental, requiring a Pixel 6 or newer on a specific Android Canary build and manual steps to enable both the terminal and hardware acceleration for better performance. This guide details how to install and run graphical apps like GIMP or LibreOffice using Flatpak, eith

Topics: android apps flatpak linux terminal

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Pebble reveals Time 2’s refreshed metal design, shares specifics about the display

androidauthority.com Unknown 2025-12-05 10:26:08

Core Devices TL;DR Pebble has revealed the design of its upcoming Time 2 smartwatch. Like the older Pebble Time Steel, the Time 2 also comes with a stainless steel body and metal buttons. It features a 1.5-inch colored e-paper display and is expected to start shipping in January 2026. The beloved barebones Pebble smart fitness trackers are set for a comeback in 2025 after more than eight years of being discontinued. Back in January this year, Pebble’s founder and ex-CEO Eric Migicovsky annou

Topics: core display pebble time watches

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Evaluating GPT5's reasoning ability using the Only Connect game show

news.ycombinator.com Alberto Manzi 2025-12-04 05:52:51

Given the proliferation of reasoning models, we wanted to go beyond knowledge-based benchmarks to test reasoning abilities such as pattern recognition, lateral thinking, abstraction, contextual reasoning (accounting for British cultural references), and multi-step inference. In addition to reasoning, we aimed to assess how effectively models make decisions when presented with judgment calls—such as choosing between making an educated guess based on available clues or calling a function to retri

Topics: clues gpt models players reasoning

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Faster NextGen Acela Trains Are Coming to the U.S. at the Worst Time

gizmodo.com David Alff 2025-12-05 10:55:33

When former President Joe Biden unveiled his US$1.9 trillion infrastructure plan in 2021, he found the perfect place to go public: Philadelphia’s 30th Street Station rail yard. Over the din of crackling wires and grumbling engines, the president made his case for revitalizing the country’s roads, ports, airports and rail lines. Behind Biden sat rows of gleaming Amtrak trains. Among them was a prototype of NextGen Acela, a sleek machine engineered to deliver the fastest passenger service in Ame

Topics: acela amtrak new rail trains

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CarPlay in iOS 26 enables ‘video in the car’, but support may take a while

9to5mac.com Zac Hall 2025-12-05 15:00:00

Apple is making a major U-turn with CarPlay after a decade of not allowing video playback. Starting with iOS 26, Apple will allow apps to display video through the CarPlay screen while parked. Support, however, is a big question mark for now. The new capability falls under the name ‘video in the car’ and is mentioned on Apple’s developer website for CarPlay: AirPlay video in the car enables people to watch their favorite videos from iPhone right on their CarPlay display when they aren’t drivin

Topics: car carplay playback support video

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OpenAI and Sam Altman are reportedly creating a startup rival to Elon Musk's Neuralink

engadget.com Unknown 2025-12-05 15:30:22

Sam Altman is preparing to co-found a new company funded by OpenAI that will go up against Elon Musk's Neuralink, The Financial Post reported. The startup, called Merge Labs, will use AI for its brain-computer interface and compete directly with Neuralink, along with other nascent companies in the field like Precision Neuroscience and Synchron. The name Merge Labs comes from a term Altman used in 2017 called "the merge" that describes the moment human brains and computers come together. The com

Topics: altman brain labs merge neuralink

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Pick up one of our favorite Bluetooth speakers while it's down to only $60

engadget.com Unknown 2025-12-05 15:50:37

Yes, summer might be coming to a close sooner than any of us would like, but that doesn't mean the outdoor fun has to end. Currently, Ultimate Ears' Wonderboom 4 Bluetooth speaker is down to $60 from $100 in blue and black. The 40 percent discount brings the speaker to a record-low price. It's one of our picks for best portable Bluetooth speakers for 2025 thanks to features like its 14 hours of battery life and its IP67 dust and waterproof rating. There are a few other great sales on UE speake

Topics: black discount percent portable speaker

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Why I finally left Spotify

techcrunch.com Amanda Silberling 2025-12-05 15:00:00

After our decade-long relationship, I’m breaking up with Spotify. It’s nothing personal. It’s just that Spotify and I have grown up, but we haven’t grown together. Over the years, I’ve been tempted to leave Spotify many times. I know that the company faces accusations of poor streaming payouts for artists, compared to its competitors, and I haven’t forgotten that it was Spotify that platformed Joe Rogan’s podcast, then exclusive to the platform, to spread misinformation about COVID-19 and othe

Topics: apple like music platform spotify

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Gemini’s ‘bouncy’ makeover starts rolling out, and it’s kinda fun to watch

androidauthority.com Unknown 2025-12-05 22:10:00

AssembleDebug / Android Authority TL;DR Google is rolling out an updated overlay for the Gemini AI assistant with a more rounded design. The new interface features an animated circular entrance that expands into a pill-shaped form, complementing the rounded design to give the overlay a fun appearance. We previously spotted these changes, and they are now appearing for some users. Google has been making great progress with Gemini, to the point that it stands on par with its competitors. Its d

Topics: animation gemini google new overlay

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Breaking: One UI 8 beta starts rolling out for the Galaxy S24 series, Z Fold 6 and Flip 6

androidauthority.com Unknown 2025-12-05 22:43:58

Joe Maring / Android Authority TL;DR Samsung has begun rolling out the first One UI 8 beta for the Galaxy S24 series, Galaxy Z Fold 6, and Galaxy Z Flip 6. The update has been currently spotted in the UK and Korea for the Galaxy S24 series, and in Korea for the Galaxy Z Fold 6 and Flip 6. However, Samsung has promised that these devices will also get the update in the US and India, so stay tuned. Samsung recently announced that the One UI 8 beta program will be available on more Galaxy devic

Topics: beta galaxy samsung ui update

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We went hands-on with Google Translate’s Duolingo rival ahead of its launch (APK teardown)

androidauthority.com Unknown 2025-12-05 23:00:05

TL;DR We managed to activate and use the Practice feature in Google Translate. This feature is effectively Google’s take on Duolingo and lets you practice a desired language. The feature currently lets you practice French or Spanish in a variety of preset scenarios, but you can also create your own lessons. Earlier this year, we discovered evidence that Google was working on a new Practice feature in Google Translate. This would allow people to (surprise) practice a desired language. Now, we’

Topics: feature google language practice translate

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Let’s discuss: What is your smartphone’s battery health percentage?

androidauthority.com Unknown 2025-12-06 00:42:43

Andy Walker / Android Authority 🗣️ This is an open thread. We want to hear from you! Share your thoughts in the comments and vote in the poll below — your take might be featured in a future roundup. I have a few older phones in my collection. I’ve rattled on about how I love each of them for a host of reasons: the Nokia 9 PureView for its quirky camera, the Galaxy Note 9 for its complete feature kit and S Pen, and the P30 Pro, which is somehow still nearly outlasting my Galaxy S24 FE on a sing

Topics: battery galaxy health older phone

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As a cell phone expert, these are the 5 cheapest carriers I recommend

androidauthority.com Unknown 2025-12-06 03:00:02

Ryan Haines / Android Authority Over the last few years, I’ve tried well over a dozen phone service providers across a variety of different price points. While I regularly recommend a few carriers above the rest, what if you’re simply looking for the cheapest service you can get without sacrificing too much in terms of quality and features? The good news is that there are plenty of options out there. Below, I’ll focus on just five carriers that I feel offer a solid mix of pricing, reputation,

Topics: data mobile plans service unlimited

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The Factory Timezone

news.ycombinator.com Unknown 2025-12-05 22:03:14

No Content Available

Topics: available content

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This Might Be the Most Massive Black Hole Ever Discovered

wired.com Jorge Garay 2025-12-05 23:47:40

Astronomers have identified what could be a new supermassive black hole, and with an estimated mass 36 billion times that of the sun, it is about 10,000 times heavier than the black hole at the center of the Milky Way. This would make it among the most massive objects ever detected. The finding, published in the Monthly Notice of the Royal Astronomical Society, was made by researchers from the Institute of Cosmology and Gravitation at the University of Portsmouth in the UK in collaboration with

Topics: black galaxy hole light massive

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ChatGPT's new subscription costs less than $5, but it's not for everyone

bleepingcomputer.com Unknown 2025-12-05 15:01:24

OpenAI has begun updating its pricing page to include a new plan called 'ChatGPT Go.' It costs 399 INR (Indian Rupee) or roughly $4.55, but there’s a catch. The GPT Go plan will be limited to certain regions, likely developing countries like India. It’s unclear if OpenAI will expand the low-cost subscription to other regions, including the United States. The ChatGPT web app warns that the Go plan is "Only available in certain regions" at ₹399 INR/month, with everything in Free. But it also of

Topics: certain chatgpt limited plan regions

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The Anti-Pattern Game

news.ycombinator.com Håkon Robbestad Gylterud 2025-12-02 23:14:40

The anti-pattern game Håkon Robbestad Gylterud Here is a small game I though of when taking a course on modal logic. It is a bit too tedious to be played by humans, but I had great fun finding a winning stategy for it – and there are still simple questions about this game I cannot answer. The rules The anti-pattern game is a two-player game. It is played using black and white pebbles (like Go). These pebbles are placed in sequence on a line. On their turn the player has a simple choice: to co

Topics: game player sequence strategy winning

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Sheet0, a data agent transform webpages to structured spreadsheets

news.ycombinator.com Unknown 2025-12-06 02:55:18

No Content Available

Topics: available content

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A Comprehensive Survey of Self-Evolving AI Agents [pdf]

news.ycombinator.com Fang 2025-12-05 21:26:32

No Content Available

Topics: available content

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Hot sale: Samsung’s new smartwatches still come with freebies!

androidauthority.com Unknown 2025-12-06 00:45:31

C. Scott Brown / Android Authority All of these offers come from Amazon. This means the free gift cards are all Amazon ones. Samsung Galaxy Watch 8 Samsung Galaxy Watch 8 + free SmartTag 2 4-Pack Samsung Galaxy Watch 8 + free SmartTag 2 4-Pack Brighter display, better battery life The Samsung Galaxy Watch 8 offers a new 'squircle' look, with new band attachments, backed by new software, a 50% brighter display over last year's model, and a slightly larger battery. The watch is available in fou

Topics: display galaxy samsung ultra watch

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Why a $599 MacBook may be the most enticing laptop for Windows 10 users later this year

zdnet.com Cesar Cadenas 2025-12-06 00:04:17

Kerry Wan/ZDNET ZDNET's key takeaways Apple could be developing a new budget-friendly MacBook for around $599. Rumors state it would house an A18 Pro chipset -- the processor found in the iPhone 16 Pro. Despite corroboration by industry experts, information is speculative. About a month ago, rumors starting surfacing that Apple was developing a lightweight MacBook that runs on iPhone hardware. Notable Apple insider Ming-Chi Kuo supported the rumors in a post on X in July, claiming the compa

Topics: apple kuo laptop macbook pro

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Visualizing quaternions: An explorable video series (2018)

news.ycombinator.com Unknown 2025-12-01 15:20:00

No Content Available

Topics: available content

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Latest Tech News

New treatment eliminates bladder cancer in 82% of patients

OpenIndiana: Community-Driven Illumos Distribution

Leaky Ice Dam Prompts Evacuations in Alaska as Record Floods Loom

The HORI Piranha Plant camera for Nintendo Switch 2 is on sale for 33 percent off

I tried Lenovo's $3,000 rollable ThinkBook and can't go back to regular-sized screens

This is the fastest local AI I've tried, and it's not even close - how to get it

Pebble Time 2 Design Reveal [video]

Study: Social media probably can’t be fixed

Hands-on: We ran full desktop Linux apps on an Android phone!

Pebble reveals Time 2’s refreshed metal design, shares specifics about the display

Evaluating GPT5's reasoning ability using the Only Connect game show

Faster NextGen Acela Trains Are Coming to the U.S. at the Worst Time

CarPlay in iOS 26 enables ‘video in the car’, but support may take a while

OpenAI and Sam Altman are reportedly creating a startup rival to Elon Musk's Neuralink

Pick up one of our favorite Bluetooth speakers while it's down to only $60

Why I finally left Spotify

Gemini’s ‘bouncy’ makeover starts rolling out, and it’s kinda fun to watch

Breaking: One UI 8 beta starts rolling out for the Galaxy S24 series, Z Fold 6 and Flip 6

We went hands-on with Google Translate’s Duolingo rival ahead of its launch (APK teardown)

Let’s discuss: What is your smartphone’s battery health percentage?

As a cell phone expert, these are the 5 cheapest carriers I recommend

The Factory Timezone

This Might Be the Most Massive Black Hole Ever Discovered

ChatGPT's new subscription costs less than $5, but it's not for everyone

The Anti-Pattern Game

Sheet0, a data agent transform webpages to structured spreadsheets

A Comprehensive Survey of Self-Evolving AI Agents [pdf]

Hot sale: Samsung’s new smartwatches still come with freebies!

Why a $599 MacBook may be the most enticing laptop for Windows 10 users later this year

Visualizing quaternions: An explorable video series (2018)

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