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Researchers map 3D genome architecture of brain glial cells during human fetal cortex development

Scientists isolated cells from developing human cortex tissue between 15 and 24 weeks gestation, fixing and preserving them for later analysis. They then used fluorescence-activated cell sorting with antibody markers like SOX2, EOMES, HOPX, OLIG2 and PU.1 to separate specific cell populations, including radial glia and oligodendrocyte precursor/microglial cells, for downstream genomic study.

Scientists identify chimeric mRNAs that produce functional proteins in immune cells

Researchers used long-read direct RNA sequencing on Oxford Nanopore's PromethION platform to identify chimeric messenger RNAs—transcripts formed by joining sequences from two different genes—in mammalian immune cells. The study found that some of these hybrid transcripts are not just sequencing artifacts but actually get translated into functional proteins that play roles in immunity.

Nature Issues Author Correction Fixing Duplicated Images in ALL Study

The authors of a study on B-cell selection thresholds in acute lymphoblastic leukaemia issued a correction after discovering an image duplication between Fig. 4d of this paper and Fig. 3l of another publication from the same research group. A separate duplication was also found within Extended Data Fig. 6e. Both figures have now been replaced with the correct original bioluminescence data and source files, including time stamps.

Nature Neuroscience issues correction to competing interests statement on endocannabinoid reward study

The journal has published an author correction to a study on endocannabinoids and reward engagement, updating the competing interests disclosure. The revised statement discloses that several authors are co-founders, board members, or the CEO of Biosyft, LLC, a company developing technologies related to the paper's subject matter. The correction applies to both the HTML and PDF versions of the article.

UNEP report: 1.5°C climate target now unreachable, warming to hit 1.8°C

A new United Nations Environment Programme report finds that current global emissions trends put the planet on track for roughly 1.8°C of warming above pre-industrial levels this century, effectively ending hopes of holding warming to the 1.5°C target set under the Paris Agreement. UNEP's executive director Inger Andersen acknowledged that countries have delayed climate action, failing to cut emissions at the pace scientists said was necessary.

Pre-collapse satellite data hint at instability before deadly Nepal-Tibet flood

Geophysicist Manoochehr Shirzaei of Virginia Tech found satellite imagery from days before the 26 August flash flood near the Nepal–Tibet border showing that a glacier section and underlying rock were accelerating in the weeks leading up to the collapse. The disaster, which killed more than 1,000 people and left over 4,000 missing, may have started with a rockslide dragging the glacier down or a glacier failure destabilizing the rocks; the exact sequence remains unclear.

How to position a Dolby Atmos soundbar for optimal sound, according to setup guidance

Proper Dolby Atmos soundbar placement requires clearing obstructions like ceiling fans and light fixtures so upward-firing drivers can bounce sound cleanly off a flat ceiling. The soundbar should sit roughly halfway up the wall, parallel to seating and near ear level, while side-firing models need unobstructed wall reflections toward the couch. Smaller soundbars without up-firing drivers, such as the Sonos Beam, offer more flexible placement for compact spaces using virtual Atmos processing instead.

Pivotal CEO Ken Karklin exits Larry Page-backed eVTOL startup

Ken Karklin has stepped down after more than four years as CEO of Pivotal, the electric vertical takeoff and landing company backed by Larry Page. The company says he is pursuing new opportunities and gave no further details. Board member Mike Ross, an aviation executive who joined in November 2025, will serve as interim CEO.

Starcloud founders plan 2029 launch of tiny probe toward Alpha Centauri

A nonprofit team led by Starcloud co-founders Philip Johnston, Adi Oltean and Ezra Feilden is developing the Fermi Explorer, a 1-kilogram, 10-centimeter cube meant to be the first human-made object aimed at another star system. The probe would spend 12 years spiraling closer to the sun to build speed before exiting the solar system in the early 2040s, then travel roughly 79,800 years before reaching Alpha Centauri.

Ford picks Apple Maps as native navigation for its Fathom EV platform

Ford VP Alan Clarke explained that after evaluating Apple, Google, and other mapping providers, the company chose Apple Maps for native integration in its upcoming Universal Electric Vehicle Platform, including the Fathom model. He cited Apple's flexibility, improved map quality, and close collaboration on EV-specific needs like range estimation and battery preconditioning as deciding factors.

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