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NMDA Receptor Antagonists: Slightly More Than You Wanted to Know

news.ycombinator.com Siggi Prendergast 2025-12-23 15:55:25

Long time no post! I got hired to do some writing and editing for a nootropics startup, but i’m finally back! I’m sticking to my theme of writing about the NMDA Receptor, this time explaining why NMDAR Antagonists can anesthetize you, treat your alzheimers, or cure your depression A Brief Technical Image The process of teasing out functions of the NMDA Receptor feels a lot like progressing through this “flowchart” (I ask that you ignore the logic of the image, just scan the vibe). Using drugs

Topics: antagonist nmda nmdar receptor subunits

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What Your Nighttime Breathing Says About Your Health

wired.com Anna Mckie 2025-12-24 12:00:00

For decades, sleep disturbance was a punch line: the cartoon dad snoring, the disgruntled partner burying their head under a pillow. But science is beginning to paint a less jovial picture. Sleep apnea—a relatively common disorder where breathing repeatedly stops and starts during sleep—is now being taken seriously as a potential biomarker for a host of major health conditions, from cardiovascular disease to Alzheimer’s, even anxiety and depression. “Sleep is just as important for health as die

Topics: apnea brain disease says sleep

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This subscription-free smart ring gave my Oura a run for its money (and it's cheaper too)

zdnet.com Matthew Miller 2025-12-24 14:00:13

RingConn Smart Ring ZDNET's key takeaways The RingConn Smart Ring is available now in three colors for $259 (regularly $279). One week battery life, lovely matte finish, powerful smartphone app, and no subscription fee. No readiness score and does not sync with third-party fitness apps other than Apple Health $169 at Amazon While I wear watches on both of my wrists, that type of wearable isn't the best for tracking sleep without being disruptive. For more than two years, I have also had an Ou

Topics: oura ring ringconn sleep smart

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The FBI Is Reportedly Holding the Missing Footage From Outside Epstein's Cell

futurism.com Unknown 2025-12-24 08:10:45

Despite official insistence to the contrary, insiders say that the US government is in possession of the "missing minute" from the footage outside of Jeffrey Epstein's Manhattan jail cell when the infamous pedophile died. Earlier this month, attorney general Pam Bondi released what the Justice Department referred to as the "full raw" surveillance footage from outside Epstein's cell — a still frame of which is shown above — documenting nearly 11 hours of the outside of the disgraced financier's

Topics: bureau epstein footage minute video

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Epic Universe Will Portal Into Your House With a TV Special

gizmodo.com Sabina Graves 2025-12-24 21:20:44

Journey through the portals of Universal Epic Universe in an upcoming one-hour NBC special hosted by Joe Manganiello (One Piece). Inside the Worlds of Epic Universe will take viewers on a tour of America’s newest state-of-the-art theme park, which features lands based on How to Train Your Dragon, Nintendo, the Universal Monsters, and Harry Potter. io9 got to visit earlier this year and can’t wait to see the park again, even through the television screen. We’re especially excited to return to th

Topics: dragon epic universal universe wicked

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Why CI/CD Still Doesn't Include Continuous Documentation?

news.ycombinator.com Neel Das 2025-12-25 16:45:42

In my 15+ years as a developer, one of the most persistent headaches I’ve seen across teams is outdated documentation. I’ll admit it, I’ve shipped features and moved on without updating the docs. A month later, a new teammate is onboarding or someone is debugging an issue, and they run into a README or guide that no longer reflects reality. It’s frustrating for them and embarrassing for us. I’m certainly not alone in this habit. Maintaining documentation is often the last thing on a developer’

Topics: ai code deepdocs docs documentation

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DOJ Has a Copy of the Epstein Jail Video With the ‘Missing Minute’: Report

gizmodo.com Matt Novak 2025-12-25 16:00:24

When the U.S. Department of Justice released a nearly 11-hour video in early July that purported to show the last time Jeffrey Epstein was seen alive, people couldn’t help but notice that there was a full minute missing. Attorney General Pam Bondi insisted there was a simple explanation: That’s just how the jail’s antiquated camera systems work. But a new report claims Bondi isn’t telling the truth. The report from CBS News cites a “government source familiar with the investigation” who told th

Topics: epstein minute missing trump video

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Avast Ye Hearties: HBO Is Auctioning Off ‘Our Flag Means Death’ Booty

gizmodo.com Cheryl Eddy 2025-12-25 16:50:48

Over two seasons, Our Flag Means Death gathered a passionate fan base as it carved out a truly unique corner of television. Part pirate adventure and part workplace comedy, it was stuffed with standout characters and heartfelt queer romance. It also offered a perfect balance of earnestness and irreverence. Suffice to say, it’s been very missed since HBO cancelled it and it was unable to find a new outlet. With the Our Flag Means Death banner lowered for good, that means the next step in saying

Topics: bonnet episode flag rhys season

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Space Force’s Secretive X-37B Is Returning to Space With New Tech

gizmodo.com Passant Rabie 2025-12-25 21:55:45

Just a few months after wrapping up its seventh test flight in orbit, Space Force’s experimental vehicle known as X-37B is ready for another go. For its upcoming mission, the spaceplane will test new technologies meant to bolster military capabilities in space, such as a navigational sensor that could replace GPS. The U.S. Space Force is set to launch the Boeing-built orbital test vehicle, designated as OTV-8, on August 21 from the Kennedy Space Center in Florida aboard SpaceX’s Falcon 9 rocket

Topics: force mission orbit space spaceplane

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Launch HN: Hyprnote (YC S25) – An open-source AI meeting notetaker

news.ycombinator.com Unknown 2025-12-26 02:24:08

Hi HN! We're Yujong, John, Duck, and Sung from Hyprnote ( https://hyprnote.com ). We're building an open-source, privacy-first AI note-taking app that runs fully on-device. Think of it as an open-source Granola. No Zoom bots, no cloud APIs, no data ever leaves your machine. Source code: https://github.com/fastrepl/hyprnote Demo video: https://hyprnote.com/demo We built Hyprnote because some of our friends told us that their companies banned certain meeting notetakers due to data concerns, or t

Topics: com fastrepl github https hyprnote

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The 10-3-2-1-0 Sleep Hack May Kick Your Restless Nights to the Curb

cnet.com See Full Bio 2025-12-26 10:30:03

After a long day of work, getting into bed and falling asleep may seem like the easiest thing in the world. However, for many, it's rarely that simple. According to the Centers for Disease Control and Prevention, more than a third of American adults don't get enough sleep. Not getting enough rest doesn't just make it harder to wake up in the morning, but it can also lead to chronic conditions like high blood pressure and heart disease. If you've been struggling with getting to sleep, it might be

Topics: bed body hours quality sleep

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The race for the thinnest foldable is on, and TECNO sets the tone with the tri-fold PHANTOM Ultimate G Fold Concept

androidauthority.com Unknown 2025-12-27 05:00:47

As the world gets excited about tri-fold phones as the next big evolution, everyone’s curious about how slim and durable they can really be. We’ve seen a few tri-folds come out already, but TECNO is truly leading the pack with the PHANTOM Ultimate G Fold Concept, setting new standards in both areas. When folded, it’s a sleek 11.49mm thick, about the same as your typical book-style foldable. And when opened up, it shrinks down to an incredibly thin 3.49mm, thanks to its innovative G-style tri-fo

Topics: concept design fold hinge tri

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Show HN: 433 – How to make a font that says nothing

news.ycombinator.com Unknown 2025-12-22 18:05:33

433 is a font that masks visible text and replaces it with dots. I'm using it in the new version of Ensō along with Coffeeshop Mode. You can see it in action here: Beautiful. Why In short: because it's the simplest way to add Coffeeshop Mode to the app. (Also, because I was curious) (OK, mainly because I was curious, Dog mode) Longer version: The previous note on Ensō ended up on the front page of HN and gave us almost 400 TestFlight testers. This is way more than I had expected. In fact

Topics: characters codepoint font glyph pen

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Show HN: 433 - How to Make a Font That Says Nothing

news.ycombinator.com Unknown 2025-12-23 00:05:33

433 is a font that masks visible text and replaces it with dots. I'm using it in the new version of Ensō along with Coffeeshop Mode. You can see it in action here: Beautiful. Why In short: because it's the simplest way to add Coffeeshop Mode to the app. (Also, because I was curious) (OK, mainly because I was curious, Dog mode) Longer version: The previous note on Ensō ended up on the front page of HN and gave us almost 400 TestFlight testers. This is way more than I had expected. In fact

Topics: characters codepoint font glyph pen

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SAVE Student Loan Borrowers, Interest Restarts on Friday. Should You Move to IBR Now?

cnet.com See Full Bio 2025-12-27 05:30:00

Interest will restart for SAVE borrowers whose loans remain in a general forbearance on Aug. 1. Viva Tung/CNET If you're a student loan borrower enrolled in SAVE, you have until the end of the week before interest will begin accruing on your loans. The change doesn't mean you have to switch repayment plans yet, but it could be a good time to make a plan. Earlier this month, the Department of Education announced interest would resume for the nearly 8 million borrowers on the Saving on a Valuabl

Topics: borrowers forbearance payments plan repayment

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Ray-Ban Meta smart glasses sales triple as EssilorLuxottica doubles down on wearables

9to5mac.com Marcus Mendes 2025-12-27 16:17:40

EssilorLuxottica, Meta’s partner in the smart glasses market and owner of brands such as Ray-Ban and Oakley, just reported stronger-than-expected quarterly revenue, driven in part by rising demand for the Ray-Ban Meta. Here’s the breakdown. In its quarterly results, EssilorLuxottica reported a 7.3% revenue increase, beating a Bloomberg-compiled analyst estimate of 5.9%. It is worth mentioning that at current exchange rates, however, revenue rose by just 3.2%, reflecting the impact of a stronger

Topics: essilorluxottica glasses meta reported smart

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Review: Fantastic Four: First Steps is the best film version so far

arstechnica.com Unknown 2025-12-27 16:10:40

Marvel Studios officially kicked off Phase Six of its cinematic universe with the release of The Fantastic Four: First Steps, and the film is already garnering solid reviews and a strong start at the box office. The cast is terrific across the board, and the production design is, well, pretty darn fantastic, evoking Disney's Tomorrowland (the park, not the film) with its 1960s retro-alt-future aesthetic. Just let your brain relax and don't try to make too much of the nonsensical plot. (Some spo

Topics: ben ebon fantastic joseph thing

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Man Spends 6 Days in the Hospital After Toothbrushing Session Goes Terribly Wrong

gizmodo.com Ed Cara 2025-12-28 02:20:45

Here’s another thing to add to the list of highly unlikely but deeply horrifying injuries you could sustain in the safety of your own home. A recent case report detailed a 50-year-old man who fainted while brushing his teeth and ended up hospitalized as a result. Doctors at The University of Tokyo Hospital described the unusual incident earlier this month in BMJ Case Reports. After fainting, the man’s toothbrush scraped the back of his throat severely enough to trap air inside, raising the risk

Topics: doctors hospitalized man report toothbrush

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Why I wear this $150 smartwatch even after testing competing Samsung and Garmin models

zdnet.com Matthew Miller 2025-12-28 06:39:00

Amazfit Balance ZDNET's key takeaways The Amazfit Balance smartwatch is available now for $150. It features a sleek and stylish design with a brilliant AMOLED display, accurate GPS, and a list of health-tracking features. Just be prepared for the data-heavy companion app, which will take some time to familiarize with. $129.99 at Amazon As a wearables reviewer here on ZDNET, I've been spoiled by the opportunity to test out flagship smartwatches from Apple, Samsung, Garmin, Coros, and many othe

Topics: amazfit balance display watch zepp

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FDA has approved Yeztugo, a drug that provides protection against HIV infection

news.ycombinator.com Bronwyn Has Always Loved Words 2025-12-28 02:06:00

An epidemic that's been sustained for 44 years might finally be quelled, with the milestone approval of the first HIV drug that offers 100% protection with its twice-yearly injections. It's a landmark achievement that stands to save millions of lives across the globe. The makers are also providing affordable access to the drug in the US and beyond, signing royalty-free licensing agreements with six generic manufacturers to produce and supply it. In the US, the Food and Drug Administration (FDA)

Topics: gilead global hiv people prep

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‘Rick and Morty’ Exec Producer Dan Harmon Is Already Thinking 2 Seasons Ahead

gizmodo.com Cheryl Eddy 2025-12-28 06:45:34

Last night brought the season eight finale of Adult Swim’s Rick and Morty—a surprisingly poignant (by Rick and Morty standards) look at how Rick and the two Beths have coped with the loss of Diane, Rick’s wife and their mother. As you’d expect, sci-fi weirdness complicates their grief—but the episode, titled “Hot Rick,” brought a sense of closure as well as the suggestion that Rick’s emotional evolution will continue in future seasons. While fans of Rick and Morty have grown used to long wait t

Topics: episode morty rick schedule season

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When Can You Get the iPhone 17? Here's What Date to Expect Its Release

cnet.com See Full Bio 2025-12-28 09:00:00

While leaks and speculation about the new iPhone have been popping up everywhere lately, one question could resolve all the others: When will the iPhone 17 be released? Once the rumored iPhone 17 -- as well as the iPhone 17 Air, Pro and Pro Max -- is revealed, we'll be able to confirm speculation about colors, display, cameras and more. We'll also learn how much the new iPhone will cost, which is also still up in the air, thanks in part to looming tariffs. Based on previous releases, the new i

Topics: 17 apple iphone release september

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Runway Launches New Aleph Model That Promises Next-Level AI Video Editing

cnet.com See Full Bio 2025-12-28 09:58:49

Runway, a pioneer in generative video, just unveiled its latest AI model called Runway Aleph that aims to redefine how people create and edit video content. Aleph builds on Runway's research into General World Models and Simulation Models, giving users a conversational AI tool that can instantly make complex edits to video footage, whether generated or existing. For instance, want to remove a car from a shot? Swap out a background? Restyle an entire scene? According to Runway, Aleph lets you do

Topics: ai aleph models runway video

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Amazon disputes report that it raised prices of popular items since Trump took office

techcrunch.com Amanda Silberling 2025-12-28 11:39:13

A report in The Wall Street Journal (WSJ) last week found that prices on Amazon’s low-cost essentials had risen since President Trump announced his plans for massive tariffs on international goods. Amazon responded with a lengthy blog post in response to the article, which describes the WSJ’s reporting as “fundamentally flawed.” WSJ analyzed the prices of 2,500 common Amazon items like cough drops, antibacterial wipes, and chicken broth, determining that the prices of these items increased on a

Topics: amazon items prices report wsj

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The first 100% effective HIV prevention drug is approved and going global

news.ycombinator.com Bronwyn Has Always Loved Words 2025-12-28 20:06:00

An epidemic that's been sustained for 44 years might finally be quelled, with the milestone approval of the first HIV drug that offers 100% protection with its twice-yearly injections. It's a landmark achievement that stands to save millions of lives across the globe. The makers are also providing affordable access to the drug in the US and beyond, signing royalty-free licensing agreements with six generic manufacturers to produce and supply it. In the US, the Food and Drug Administration (FDA)

Topics: gilead global hiv people prep

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Crunchyroll Is Bringing More Anime to Movie Theaters

gizmodo.com Justin Carter 2025-12-27 22:30:38

The last few years have seen anime movies and premiere episodes take to the big screen and make a ton of money, so Crunchyroll is getting on that with its new Anime Nights program. During San Diego Comic-Con, the streamer/distributor revealed its plan to put an anime on the silver screen for the third Monday of every month to “honor the past, elevate the present, and celebrate the future of anime.” The titles will range from fan favorites and anniversaries to “curated” TV episodes, and even pre

Topics: anime crunchyroll dragon episodes experience

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Trump temporarily drops export controls to smooth negotiations with China

engadget.com Unknown 2025-12-29 16:00:21

After previously saying that the US would block exports of key AI chips to China, Donald Trump's administration may have backtracked. The US will now temporarily block restriction on exports of chips and other technology to China, the Financial Times reported. The aim is to help Trump book a meeting with China President Xi Jinping later this year in order to strike a trade deal, according to people familiar with the matter. Export controls are dictated by the US Commerce Department, which was r

Topics: ai china chips department trump

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Survey shows 9 out of 10 people demand this camera feature on base Pixel 10

androidauthority.com Unknown 2025-12-30 00:30:53

Google One of the most intriguing and persistent Google Pixel 10 series rumors is that the base Pixel 10 could finally get a telephoto camera. This should theoretically enable much-improved camera zoom without splashing out on a Pro phone. I personally welcome this news, but do readers feel the same? We ran polls on the website, our Twitter page, and our YouTube channel. The results are finally in, and here’s how you voted. Do you want the Pixel 10 to have a zoom camera? The results were c

Topics: 10 camera pixel telephoto zoom

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Claude Code Router

news.ycombinator.com Unknown 2025-12-29 14:19:23

Claude Code Router 中文版 A powerful tool to route Claude Code requests to different models and customize any request. ✨ Features Model Routing : Route requests to different models based on your needs (e.g., background tasks, thinking, long context). : Route requests to different models based on your needs (e.g., background tasks, thinking, long context). Multi-Provider Support : Supports various model providers like OpenRouter, DeepSeek, Ollama, Gemini, Volcengine, and SiliconFlow. : Support

Topics: claude code deepseek model router

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From Cheating Exposés to Dating Background Checks, TikTok Detectives Are Thriving

wired.com Tom Ward 2025-12-30 03:00:00

It’s a dark November night in Los Angeles. The car in front is lit by its rear lights only. After driving for 20 miles, it stops, suddenly, in the middle of the street. A man in a dark t-shirt gets out and runs towards an apartment. A woman appears and jumps up, wrapping her legs around him. They start making out before going to get tacos and, later, returning to her place. At 6 a.m. the next morning his car is still outside the woman’s apartment. A few hours later, they emerge holding hands, h

Topics: investigator like people private stephanie

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Latest Tech News

NMDA Receptor Antagonists: Slightly More Than You Wanted to Know

What Your Nighttime Breathing Says About Your Health

This subscription-free smart ring gave my Oura a run for its money (and it's cheaper too)

The FBI Is Reportedly Holding the Missing Footage From Outside Epstein's Cell

Epic Universe Will Portal Into Your House With a TV Special

Why CI/CD Still Doesn't Include Continuous Documentation?

DOJ Has a Copy of the Epstein Jail Video With the ‘Missing Minute’: Report

Avast Ye Hearties: HBO Is Auctioning Off ‘Our Flag Means Death’ Booty

Space Force’s Secretive X-37B Is Returning to Space With New Tech

Launch HN: Hyprnote (YC S25) – An open-source AI meeting notetaker

The 10-3-2-1-0 Sleep Hack May Kick Your Restless Nights to the Curb

The race for the thinnest foldable is on, and TECNO sets the tone with the tri-fold PHANTOM Ultimate G Fold Concept

Show HN: 433 – How to make a font that says nothing

Show HN: 433 - How to Make a Font That Says Nothing

SAVE Student Loan Borrowers, Interest Restarts on Friday. Should You Move to IBR Now?

Ray-Ban Meta smart glasses sales triple as EssilorLuxottica doubles down on wearables

Review: Fantastic Four: First Steps is the best film version so far

Man Spends 6 Days in the Hospital After Toothbrushing Session Goes Terribly Wrong

Why I wear this $150 smartwatch even after testing competing Samsung and Garmin models

FDA has approved Yeztugo, a drug that provides protection against HIV infection

‘Rick and Morty’ Exec Producer Dan Harmon Is Already Thinking 2 Seasons Ahead

When Can You Get the iPhone 17? Here's What Date to Expect Its Release

Runway Launches New Aleph Model That Promises Next-Level AI Video Editing

Amazon disputes report that it raised prices of popular items since Trump took office

The first 100% effective HIV prevention drug is approved and going global

Crunchyroll Is Bringing More Anime to Movie Theaters

Trump temporarily drops export controls to smooth negotiations with China

Survey shows 9 out of 10 people demand this camera feature on base Pixel 10

Claude Code Router

From Cheating Exposés to Dating Background Checks, TikTok Detectives Are Thriving

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