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Virtual Cells

Virtual cells Digital twins of biological cells—often referred to as virtual cells or whole-cell models (WCMs)–aim to recreate every relevant molecular process of a living cell in silico. This interdisciplinary endeavor marries systems biology, computational modeling, high-performance computing, and, increasingly, AI. All models are wrong, but some are alive. Somewhere in a data center right now, a virtual bacterium is dividing for the millionth time. Somewhere else, an AI-enhanced model is l

Here’s My Experience With 5 Cheap Gadgets I Bought From AliExpress

If you're shopping online, you may have noticed products from Temu and AliExpress often come up in your shopping search. These items are so cheap that you may wonder if it's really a steal or if you should stay away. I was in that boat as well. And I love a good YouTube video where the host tests cheap tech from low-cost retailers. So, curious as I am, I decided to try my hand at testing cheap home products from the popular discount marketplace, AliExpress. Now, when shopping for a new piece of

Octobass

Composers and orchestras like to use their lowest instruments sparingly, for maximum impact. Few instruments go lower and are used more sparingly than the huge and strange octobass, one of the rarest classic instruments in existence. Invented in 1850 by Jean-Baptiste Vuillaume, the octobass was intended to bring an extremely deep rumble to the orchestra sound. The three-stringed instrument stands between 11 and 12 feet tall, about twice the height of a double bass. This giant bass produces soun

No, the 16 billion credentials leak is not a new data breach

News broke today of a "mother of all breaches," sparking wide media coverage filled with warnings and fear-mongering. However, it appears to be a compilation of previously leaked credentials stolen by infostealers, exposed in data breaches, and via credential stuffing attacks. To be clear, this is not a new data breach, or a breach at all, and the websites involved were not recently compromised to steal these credentials. Instead, these stolen credentials were likely circulating for some time,

In praise of “normal” engineers

This article was originally commissioned by Luca Rossi (paywalled) for refactoring.fm, on February 11th, 2025. Luca edited a version of it that emphasized the importance of building “10x engineering teams” . It was later picked up by IEEE Spectrum (!!!), who scrapped most of the teams content and published a different, shorter piece on March 13th. This is my personal edit. It is not exactly identical to either of the versions that have been publicly released to date. It contains a lot of the so

Estrogen: A Trip Report

The following blog post discusses my personal experience of the phenomenology of feminising hormone therapy. It will also touch upon my own experience of gender dysphoria. I wish to be clear that I do not believe that someone should have to demonstrate that they experience gender dysphoria – however one might even define that – as a prerequisite for taking hormones. At smoothbrains.net, we hold as self-evident the right to put whatever one likes inside one’s body; and this of course includes hor

Trump gives TikTok another ban extension

is a senior policy reporter at The Verge, covering the intersection of Silicon Valley and Capitol Hill. She spent 5 years covering tech policy at CNBC, writing about antitrust, privacy, and content moderation reform. For the third time, President Donald Trump has extended the deadline for TikTok to spin out from its Chinese parent company or face a US ban. As White House Press Secretary Karoline Leavitt confirmed in a statement Tuesday, Trump signed an executive order on Thursday extending the

Midjourney adds AI video generation

AI company Midjourney has released its first video model. This initial take on AI-generated video will allow users to animate their images, either ones made in Midjourney or uploaded from a different source. The initial results will be five-second clips that a user can opt to extend by four seconds up to four times. Videos can be generated on web only for now and require at least a $10 a month subscription to access. Introducing our V1 Video Model. It's fun, easy, and beautiful. Available at 10

IEEE Member Shrinivass A.B. Serves as Judge at Regeneron ISEF 2025, Celebrating Innovation at the Intersection of Technology and Humanity

In May 2025, IEEE Computer Society member and technology professional Shrinivass Arunachalam Balasubramanian joined an international panel of experts at the Regeneron International Science and Engineering Fair (ISEF), serving as a Grand Award Judge in the Technology That Enhances the Arts (TECA) category. Held in Columbus, Ohio, the event marked the 75th anniversary of ISEF—the world’s largest and most prestigious STEM research competition for high school students. The fair welcomed over 1,600

How teachers are fighting AI cheating with handwritten work, oral tests, and AI

A hot potato: The fear that generative AI tools such as ChatGPT would lead to a generation of students cheating and plagiarizing work has come to pass. The situation is so bad that educators are now looking at multipe ways to stop the problem, or at least make the practice much more difficult. Ironically, one of them is to use AI. Speaking about AI-cheat students, Gary Ward, a teacher at Brookes Westshore High School in Victoria, British Columbia, told Business Insider, "Some of the ones that I

Google Phone’s Material 3 Expressive revamp and new call gestures are starting to roll out

Aamir Siddiqui / Android Authority TL;DR Google has started rolling out the Phone app’s Material 3 Expressive redesign on the beta channel. The updated interface brings visual changes to the in-call screen and Recent tab. It also introduces two new incoming call gesture options for the incoming call screen. Google has started rolling out the Material 3 Expressive redesign of its Phone app to some users, which we first spotted in a teardown late last month. It includes visual changes for the

Nintendo just revealed Pauline as a surprise character in Donkey Kong Bananza

Nintendo just dropped a ton of details about the next major Switch 2 first-party game. Donkey Kong Bananza was the star of a Nintendo Direct livestream this morning and it was filled to the brim with nifty tidbits to get fans excited about the 3D platformer. The biggest news is the addition of Pauline as DK's sidekick. She goes all the way back to the original Donkey Kong arcade game. Nintendo really pulled a fast one here, as the first trailer showed the sidekick as an anthropomorphic rock of

In Praise of "Normal" Engineers

This article was originally commissioned by Luca Rossi (paywalled) for refactoring.fm, on February 11th, 2025. Luca edited a version of it that emphasized the importance of building “10x engineering teams” . It was later picked up by IEEE Spectrum (!!!), who scrapped most of the teams content and published a different, shorter piece on March 13th. This is my personal edit. It is not exactly identical to either of the versions that have been publicly released to date. It contains a lot of the so

RIP Microsoft Passwords: Here's How to Set Up a Passkey Before the August Deadline

Risky password habits can have big consequences, and some companies are making it easier to stay secure online by ditching decades-old password methods and implementing passkeys instead. Microsoft intends to do the same starting in August. Whether you have an easy-to-guess password or it's leaked in a company data breach, if hackers get hold of it, it can open the door to identity theft and fraud. A recent CNET survey found that 49% of US adults have risky password habits, like using the same p

Show HN: EnrichMCP – A Python ORM for Agents

EnrichMCP The ORM for AI Agents - Turn your data model into a semantic MCP layer EnrichMCP is a Python framework that helps AI agents understand and navigate your data. Built on MCP (Model Context Protocol), it adds a semantic layer that turns your data model into typed, discoverable tools - like an ORM for AI. What is EnrichMCP? Think of it as SQLAlchemy for AI agents. EnrichMCP automatically: Generates typed tools from your data models from your data models Handles relationships between

First Call of Duty Black Ops 6 Double XP Weekend Dates Announced for Season 4

It's finally time to get ahead on the battle pass with the first set of double XP boosts in Black Ops 6 Season 4. Developer Treyarch has your back with a new double XP weekend featuring three boosts for players to take advantage of -- you'll be able to speed through account levels, weapon attachment unlocks and battle pass tiers to kickstart your advancement of the newest seasonal content. This double XP weekend runs from Thursday to Monday. Anyone playing Black Ops 6 during the event period ha

Webinar: Stolen credentials are the new front door to your network

Cybercriminals no longer need zero-day exploits or other vulnerabilities to breach your systems—these days, they just log in. On July 9th at 2:00 PM ET, BleepingComputer and SC Media will co-host a live webinar with identity security expert Darren Siegel of Specops Software (part of Outpost24), exploring how threat actors are increasingly breaching networks by simply logging in with stolen credentials. The webinar "Stolen credentials: The New Front Door to Your Network" will unpack the real-wo

Painting with Math: A Gentle Study of Raymarching (2023)

Most of my experience writing GLSL so far focused on enhancing pre-existing Three.js/React Three Fiber scenes that contain diverse geometries and materials with effects that wouldn't be achievable without shaders, such as my work with dispersion and particle effects. However, during my studies of shaders, I always found my way to Shadertoy, which contains a multitude of impressive 3D scenes featuring landscapes, clouds, fractals, and so much more, entirely implemented in GLSL. No geometries. No

We Can Just Measure Things

We Can Just Measure Things This week I spent time with friends to letting agents go wild and see what we could build in 24 hours. I took some notes for myself to reflect on that experience. I won't bore you with another vibecoding post, but you can read Peter's post about how that went. As fun as it was, it also was frustrating in other ways and in entire predictable ways. It became a meme about how much I hated working with Xcode for this project. This got me thinking quite a bit more that th

Inside Microsoft’s complicated relationship with OpenAI

is a senior editor and author of Notepad , who has been covering all things Microsoft, PC, and tech for over 20 years. Beyond the selfies between Microsoft CEO Satya Nadella and OpenAI CEO Sam Altman, and the friendly conversations between the pair on stage, all is not well with Microsoft’s $13 billion AI investment. Over the past year, multiple reports have painted a picture of a Microsoft and OpenAI relationship that is straining under pressure. As OpenAI battles for access to more compute p

Netflix signs deal to host live TV channels in France

Everything old is new again. Netflix just inked a deal to air live television broadcasts in France , turning the streaming giant into, well, regular TV. The platform will host five traditional broadcast channels from French TV behemoth TF1. Subscribers in the region will have access to live programming and on-demand content. The partnership officially begins next summer. The channels underneath TF1's umbrella air everything from reality shows like The Voice to live sports, including the French

OpenAI’s Sam Altman discusses GPT-5 release date

ChatGPT's next big upgrade, or the new foundational model 'GPT-5,' is being prepared for public release, but OpenAI won't share the specifics. In a recent interview, Sam Altman, CEO and co-founder of OpenAI, confirmed that ChatGPT's GPT-5 model release date is sometime in summer, but it depends on a number of factors. OpenAI has internal benchmarks and other standards set for GPT-5, and unless those are met, OpenAI might not release the model to the public. Sam added that he doesn't know 'exa

SpaceX Starship Explodes in Spectacular Fireball at Texas Test Facility

The upper stage prototype, designated Ship 36, exploded shortly before midnight local time on June 18 during routine preparations for an upcoming test flight. SpaceX is in the midst of preparing for Starship’s next fully integrated test, known as Flight 10. The last several tests haven’t gone well, but this prototype never even left the ground. The explosion—as shown in spectacular footage from NASASpaceFlight.com—occurred at SpaceX’s Massey facility, a test site located several miles from the

This Arlo Home Security Bundle Now Costs Peanuts, Includes 2 Cameras and a Smart Doorbell

For the security of your house, one indoor camera is a fair beginning, yet complete peace of mind results from extensive protection. That’s what Arlo offers with its new whole home security bundle which is a one-stop solution to watch over all the important areas of your house. Sometimes, simply having visible security modules is a powerful deterrent and make your house a less attractive target for would-be burglars. Right now, Amazon is offering this essential bundle at an all-time low, the pe

What Do Your Poops Mean? Experts Share What You Can Learn From Your Bowel Movements

Nobody enjoys talking about their bodily functions, and bowel movements are right up there in the uncomfortable stakes. But once you get beyond the embarrassment, there is a lot that you can learn about yourself if you know what to pay attention to. How often you poop, how long it takes and what your stools look like can reveal a lot about your health. Knowing what to pay attention to is important. That's why we spoke with three gastroenterologists about the frequency of regular bowel movements