GoKawiil
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Researchers at St. Jude Children's Research Hospital used CRISPR-Cas9 screening in mouse T cell models to identify ZMYND8 as a regulator of T cell exhaustion. Removing ZMYND8 boosted IL-2 signalling in antigen-specific CD8+ T cells, including those engineered with CAR constructs, helping the cells retain function against tumours in mouse models.
Researchers used gene-edited human pluripotent stem cell lines carrying TSC mutations to generate astrocytes and brain organoids, finding that hyperactivation of the mTORC1 signaling pathway directly causes astrocytes to become reactive without requiring signals from neurons or other cell types. The work relied on multiple hES and hiPS cell lines that were verified for correct gene editing, pluripotency, and genomic integrity before differentiation experiments.
Researchers built a combined dataset of DNA and fossil traits to reconstruct how living bat families relate to extinct lineages and when they diverged. The study compiled morphological data from 44 pre-Quaternary fossil bats alongside genome-matched representatives of every living bat family, filtering out unreliable or redundant characters before merging this with neutral genomic sites. They applied a fossilized birth-death modeling approach to jointly estimate the bat family tree and its divergence timeline.
Researchers characterized a hydrolase enzyme from a methanogen archaeon and used it to reveal structural details of archaeal peptidoglycan-like cell wall material, known as pseudopeptidoglycan. The work, conducted across several European research institutions including the Institut Pasteur, was supported by multiple national and European science funding bodies.
A methods disclosure describes how researchers sourced and synthesized kinase inhibitors—including ponatinib, asciminib, imatinib, dasatinib and osimertinib—and cultured K562 and HEK293T cell lines to test them. The report details engineered K562 stable lines carrying BCR::ABL1 mutations, created via enzymatic mutagenesis of a pUltra vector, used to evaluate inhibitor activity in cell-based assays.
Researchers analyzing human liver tissue from pancreatic cancer patients, alongside mouse models, report that hepatocytes supply the amino acid serine to metastasizing pancreatic cancer cells, supporting their growth in the liver. The work, which included tissue from the University of Nebraska Medical Center's Rapid Autopsy Program, used immunohistochemistry to examine markers including PHGDH, albumin, CK19, Ki67 and FOXO3A in liver samples.
Researchers received ethical approval from a major UK retail bank's privacy governance body in August 2024 to study transaction data from women customers, aiming to identify behavioral signatures of financial abuse. The study compared a victim-survivor group against a matched control group, using strict filtering criteria such as account type, age, and transaction frequency to build comparable samples from the bank's 28 million customers.
A research team synthesized a series of short peptides—including DILT1 through DILT5 and related sequences—using automated solid-phase peptide synthesis to create multichannel nanofibrils. The peptides self-assemble into structures whose lattice geometry is dictated by their specific amino acid sequences, producing hexagonal channel arrangements at the nanoscale.
Researchers reported an optical frequency reference using trapped lutetium ions (Lu+) whose accuracy was experimentally verified to the 19th digit. The system uses paired ion interrogation with Doppler cooling, a Ramsey-based HA–HR sequence, and active magnetic-field feedback via shim coils to suppress Zeeman shift drift, alongside auxiliary spectroscopy checks to keep the clock laser and field measurements calibrated.
Researchers from the PsychAD consortium describe training single-nucleus transcriptomic imputation models (snTIMs) using single-nucleus RNA sequencing data from more than 6 million nuclei drawn from brain tissue of 1,494 donors. The work involved dividing donors into ancestry groups, harmonizing genotype data across multiple sequencing and array platforms, and building ancestry-specific reference panels to align training and target cohorts, including data from the Million Veteran Program.
Researchers analyzed length-of-day (LOD) records from 1964 to 2019, after removing known effects from the atmosphere, oceans, tides and surface mass changes, to isolate multidecadal variations. They modeled these residual variations using torque equations that account for gravitational pull from the inner core alongside electromagnetic and topographic coupling at the core-mantle boundary, finding that gravitational torque from the inner core contributes to the slow, multidecadal changes in how long a day lasts.
Researchers analyzed geolocated outbreak data for 32 environmentally linked emerging infectious diseases, combining these with global datasets on socio-environmental factors such as land use, climate and biodiversity. Using disease-specific driver hypotheses developed with experts across virology, ecology and public health, they built geospatial statistical models to identify common human-caused patterns behind where outbreaks occur.