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OpenAI Claims New AI Model Solved Navier-Stokes Millennium Problem

OpenAI says an unreleased AI model produced a proof addressing the Navier-Stokes existence and smoothness problem, one of the seven Millennium Prize math problems, completing the work in 88 hours. The proof reportedly identifies a scenario where the fluid-dynamics equations break down mathematically, though researchers stress this doesn't mean real fluids like water would physically behave that way.

ASML plans 12-inch mask for High-NA EUV, aiming for 2033 rollout

ASML is developing a larger 12-inch mask format for its next-generation High-NA EUV lithography systems, letting them print chips as large as those made with current EUV tools. The company expects a pilot line by 2031 and high-volume production by 2033, with CTO Marco Pieters saying the shift could boost system productivity by 40% if the industry adopts it together.

Dell's AW3926QW brings 39-inch 5K2K OLED gaming monitor at $1,100, undercutting LG rival

Dell has launched the Alienware AW3926QW, a 39-inch 5120x2160 ultrawide OLED gaming monitor with 165Hz refresh rate and a 1500R curve, priced at $1,100. It uses an RGB stripe subpixel layout with a glossy coating and LG Display's latest Tandem WOLED panel, differing from the LG 39GX950B's RGWB matte design despite sharing the same resolution and refresh specs.

Harvard lab predicts 75% of suicide attempts within a week using daily monitoring

A multiyear Harvard study led by psychologist Matthew K. Nock tracked over 600 high-risk adults and adolescents and successfully predicted 75 percent of suicide attempts and 87 percent of suicide-related events in the seven days before they happened. The findings, set to publish in the Journal of Psychopathology and Clinical Science, mark a sharp improvement over traditional models that forecast risk months or years out rather than days.

Study of 1 million people maps genetic links to Big Five personality traits

A large-scale genetic study analyzed data from roughly one million people to identify genetic variants associated with the Big Five personality traits—openness, conscientiousness, extraversion, agreeableness, and neuroticism. The research aimed to uncover the biological underpinnings of personality by pinpointing specific genomic regions correlated with these traits.

Researchers use AlphaFold database to identify TM184C as a GPCR-like regulator

A research team mined all 214.5 million structure predictions in Google DeepMind's AlphaFold database to search for undiscovered 7TM (seven-transmembrane) folds resembling G-protein-coupled receptors. Using the rhodopsin structure as a reference and the TM-align algorithm, they identified TM184C as a previously unrecognized GPCR-like protein involved in regulating cell-to-cell exchange and autophagy. The analysis required processing 24 tebibytes of compressed structural data on university supercomputing clusters.

Study maps mutational signatures behind prostate cancer using largest PPCG genome dataset

Researchers analyzed whole-genome sequencing data from 1,001 prostate cancer patients (1,172 tumour samples) collected through the PPCG consortium, applying computational tools to classify structural variants, including simple, complex, and chromothripsis-related genomic rearrangements. The team combined breakpoint detection, copy number segmentation, and statistical tests to build a detailed picture of mutational processes driving the disease.

Study finds phone-based tutoring sustained learning gains across five countries during crises

Researchers tracked children in five countries using baseline and endline phone surveys to measure whether mobile education programmes helped maintain learning during disruptions like COVID-19 lockdowns. The assessments, adapted from the ASER numeracy test, measured math skills alongside child wellbeing and parental engagement, with strict quality checks like time limits and requiring children to explain their answers to prevent parental assistance. Data collection methods varied by country, including a partial baseline in Nepal and administrative data in Kenya.

Study links serpin proteins to pancreatic cancer subtype diversity and immune escape

Researchers combined single-cell RNA sequencing from human and mouse pancreatic tumours with protein localization databases, CRISPR dependency screens and functional annotation to identify tumour-secreted genes that shape cancer cell diversity and suppress immune responses. The filtering pipeline pinpointed a group of serpin family proteins acting through myeloid cells as key drivers of this immune evasion process. The work narrows a large pool of candidate genes down to those most likely to influence how pancreatic tumours interact with surrounding immune cells.

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