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The Sudden Surges That Forge Evolutionary Trees

Over the last half-billion years, squid, octopuses and their kin have evolved much like a fireworks display, with long, anticipatory pauses interspersed with intense, explosive changes. The many-armed diversity of cephalopods is the result of the evolutionary rubber hitting the road right after lineages split into new species, and precious little of their evolution has been the slow accumulation of gradual change. They aren’t alone. Sudden accelerations spring from the crooks of branches in evo

Scientists Say They May Have Just Figured Out the Origin of Life

How did the building blocks of life come together to spawn the first organisms? It's one of the most longstanding questions in biology — and scientists just got a major clue. In a new study published in the journal Nature, a team of biologists say they've demonstrated how RNA molecules and amino acids could combine, by purely random interactions, to form proteins — the tireless molecules that are essential for carrying out nearly all of a cell's functions. Proteins don't replicate themselves b

How to Scale Proteomics

A cell is a vibrating bag of molecules, densely packed with DNA, proteins, RNAs, and lipids. The ratios of these molecules are not balanced, though. A typical HeLa cell, widely used as a model to study cancer in the laboratory, has about 20 times more protein than DNA by mass. Such imbalances are pervasive across the tree of life, but proteins are always the heaviest and most diverse group of molecules within a cell. A single human cell encodes more than 20,000 proteins, each built from 20 stan

Super-resolution microscopes reveal new details of cells and disease

Using a tiny, spherical glass lens sandwiched between two brass plates, the 17th century Dutch microscopist Antonie van Leeuwenhoek was the first to officially describe red blood cells and sperm cells in human tissues, and observe “animalcules” — bacteria and protists — in the water of a lake. Increasingly powerful light microscopes followed, revealing cell organelles like the nucleus and energy-producing mitochondria. But by 1873, scientists realized there was a limit to the level of detail. W

Traditional Chinese Medicine Has Not Been Vindicated by Science

People love to show that skeptics were wrong about something, especially when national pride hangs in the balance. The South China Morning Post published the following headline on November 3rd: “Scientists find traditional Chinese medicine is based on a complex network of proteins – 3,000 years before modern science.” The article points out that respectable editorials in the scientific literature had repeatedly referred to traditional Chinese medicine (TCM) as “largely just pseudoscience” and “

We’ve had a Denisovan skull since the 1930s—only nobody knew

A 146,000-year-old skull from Harbin, China, belongs to a Denisovan, according to a recent study of proteins preserved inside the ancient bone. The paleoanthropologists who studied the Harbin skull in 2021 declared it a new (to us) species, Homo longi. But the Harbin skull still contains enough of its original proteins to tell a different story: A few of them matched specific proteins from Denisovan bones and teeth, as encoded in Denisovan DNA. So Homo longi was a Denisovan all along, and thank

Toxic Proteins for Drug Discovery

Noah Whiteman, professor of evolutionary biology at UC Berkeley, writes about how toxins are repurposed into medicines for Issue 06. Whiteman’s recent book is called “Most Delicious Poison.” Ella Watkins-Dulaney for Asimov Press. When you hear the word "poison," perhaps you picture a Victorian-era cobalt bottle labeled "NOT TO BE TAKEN" or the iconic pictogram of a leering skull and crossbones. What probably does not come to mind, however, are the dried white beans in your kitchen pantry, the

We’ve had a Denisovan skull since the 1930s—only nobody knew

A 146,000-year-old skull from Harbin, China, belongs to a Denisovan, according to a recent study of proteins preserved inside the ancient bone. The paleoanthropologists who studied the Harbin skull in 2021 declared it a new (to us) species, Homo longi. But the Harbin skull still contains enough of its original proteins to tell a different story: A few of them matched specific proteins from Denisovan bones and teeth, as encoded in Denisovan DNA. So Homo longi was a Denisovan all along, and thank

This company is trying to make a biodegradable alternative to spandex

“True circularity has to start with raw materials,” says Peña. “We talk about circularity across many industries, but for textiles, we must address what we’re using at the source.” Engineered from recombinant DNA, SELPs are copycat proteins inspired by silk and elastin that can be customized for qualities like tensile strength, dye affinity, and elasticity. Silk’s amino acid sequences—like glycine-alanine and glycine-serine—give fibers strength, while elastin’s molecular structure adds stretchi